晚期肺癌患者光子刀治疗前后检测肺泡灌洗液血清中铁蛋白CA199CEA的意义临床医学.docVIP

晚期肺癌患者光子刀治疗前后检测肺泡灌洗液血清中铁蛋白CA199CEA的意义临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：晚期肺癌患者光子刀治疗前后检测肺泡灌洗液血清中铁蛋白CA199CEA的意义临床医学 1 1．2治疗方法 3 1．3标本采集 4 1．4测定方法 4 1．5统计学方法 4 文2：女性冠心病患者血清血尿酸测定的意义临床医学 7 1资料与方法 8 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 12 正文 晚期肺癌患者光子刀治疗前后检测肺泡灌洗液血清中铁蛋白CA199CEA的意义临床医学 文1：晚期肺癌患者光子刀治疗前后检测肺泡灌洗液血清中铁蛋白CA199CEA的意义临床医学 Abstract： ObjectiveTo explore the clinical value of the detection of serum ferritin (SF), carbohydrate antigen199 (CA199) and carcinoembryonic antigen (CEA) in bronchoalveolar lavage fluid (BALF) and plasm on terminal lung cancer patients treated by photon knife. MethodsImmunoradiometric assay (IRMA) was utilized to determine SF, CA199 and CEA in 48 patients with teminal lung cancer treated by photon knife (trial group) and in 58 patients with benign lung disease (control group). ResultsThe concentratio of SF, CA199 and CEA in BALF and plasm were significantly higher in the trial group than in the control group (P). In the trial group, each indicatrix of BALF was higher than that of plasm or serum (P). In the trial group, the concentratio of SF, CA199 and CEA at each stage during radiotherapy were significantly lower than that before radiotherapy (P). The indicatrix descent was more obvious within the fit three months after radiotherapy. ConclusioF, CA199 and CEA are negatively correlative with terminal lung cancer patients condition after radiotherapy, especially seitive in BALF. It is significant to determine SF, CA199 and CEA in terminal lung cancer patient treated by photon knife, for they may be used to reflect the condition and assess the prognosis. Key words： pulmonary neoplasm; photon knife; bronchoalveolar lavage fluid; ferritin; carbohydrate antigen; carcinoembryonic antigen 晚期肺癌患者常常采用光子刀 治疗 以提高生活质量，延长其生存期，但光子刀治疗肺癌的剂量常较难掌握，剂量不足易导致肿瘤的复发，剂量过大易导致各种并发症的发生。我院自2005年1月—2007年6月通过联合检测48例晚期肺癌患者光子刀治疗前后支气管肺泡灌洗液（BALF）、血清中的铁蛋白（SF）、糖链抗原199（CA199）、癌胚抗原（CEA）的变化，探讨其指导光子刀剂量及判断晚期肺癌患者预后的临床意义，现报告如下。 1对象与方法 1．1对象