老年2型糖尿病伴高脂血症患者对尿白蛋白水平的影响及相关因素分析.docVIP

·726 · · 论 著 · 老年2型糖尿病伴高脂血症患者对尿白蛋白水平的影响及 相关因素分析 吴雯，刘军，赵燕萍 【摘要】 目的 探讨老年2型糖尿病伴高脂血症患者对尿白蛋白水平的影响及相关因素分析。方法 检测单纯 高脂血症患者1464例 (HL 组)、单纯2型糖尿病患者469例 (T2DM 组)、2型糖尿病伴高脂血症患者703例 (T2DML 组)和正常对照人群1301例 (C 组)的空腹血糖 (FBG) 和餐后2h 血 糖 ( 2hBG)、 血脂和尿蛋白肌酐比值 测定 (ACR) 。结果 T2DML组 ACR 明显高于HL 组及T2DM 组，此3组ACR 均明显高于C 组，差异有统计学意义 (P0.05)。Spearman 相关分析显示： ACR 与 FBG(r=0.177,P0.05)、2 hBG(r=0.167,P0.05)、 体质指数 (BMI)(r=0.087,P0.05)、 收缩压 (SBP)(r=0.212,P0.05)、 舒张压 (DBP)(r=0.133,P0.05)、 总胆 固醇 (TC)(r=0.084,P0.05)、 三酰甘油 (TG)(r=0.133,P0.05) 呈正相关，多元逐步回归分析显示 ACR 与年龄、 FBG、SBP、 性别呈独立正相关 (P0.05)。 结论 单纯高脂血症及单纯糖尿病引起尿蛋白排泄率增高，2型 糖尿病伴高脂血症尿蛋白排泄增高更明显，脂代谢紊乱可能加重尿蛋白排泄。 【关键词】 高脂血症；糖尿病，2型；尿白蛋白肌酐比值 【中图分类号】 R589.21 【文献标识码】 A 【文章编号】1007-9572(2011)03-0726-02 Effect of Hyperlipidemia on Urine Album in Elderly Type 2 Diabetic Patients and Ananlysis of Its Relative Risk Factors WU Wen,LIU Jun, ZHAO Yan -ping. Shanghai Fijth Peoples Haspital,Fudan University,Jiangchuan Community Health Center of Shanghai Minhang District,Shanghai 200240,China 【Abstract】 Objective To investigate the effect of hyperlipidemia on urine album in elderly patients with type 2 diabe- tes mellitus complicated by hyperlipidemia and to analyze its relative risk factors. Methods Totally 1464 patients with hyperlipi- demia(HL group),469 patients with type 2 diabetes mellitus(T2DM group),703 patients with both hyperlipidemia and 2 type diabetes mellitus(T2DML group)and 1301 normal control subjects(NC group) were enrolled. Fasting blood glucose(FBG), 2-hour postprandial blood glucose (2hPG), blood lipid,and albumin - to -creatinine ratio(ACR) were measured for all the subjects. Results The ACR of the T2DML group was significantly higher than that of the HL and T2DM groups, and the ACRs of this three groups were all significantly higher than that in the NC group(P0.05). Spearman correlation analysis showed that ACR was positively correlated to FBG(r=0. 177