糖尿病与食管癌病例对照研究的Meta分析.docVIP

· 289 · · 医 学 循 证 · 糖尿病与食管癌病例对照研究的 Meta 分析 石益海，侯丽英，裘炯良 【摘要】 目 的 探讨糖尿病与食管癌的关系。方法 以“食管癌、食管肿瘤、糖尿病、 esophageal cancer 、e- sophageal neoplasms、diabetes mellitus”为关键词，计算机检索中国期刊全文数据库 (CNKI)、 中国生物医学文献数据 库 (CBM)、 维普中文科技期刊数据库 (VIP)、Cochrane Library、PubMed、EMbase和 Ovid, 检索时间均从建库至2012 年4月。纳入所有研究糖尿病与食管癌病因相关性的病例-对照研究。采用 RevMan 5.0软件进行 Meta分析。结果 最终纳入6篇病例对照研究，其中病例组(食管癌患者)1553例，对照组(非肿瘤患者)57767例；两组暴露糖尿 病患者分别为139例和2294例。 Meta 分析结果显示，各研究间存在统计学异质性〔合并效应量 OR=1.60,95% CI (1.13,2.26)〕。亚组分析显示，无论男性还是女性，病例组的糖尿病患病率均较对照组增高，且女性较男性糖尿病 人群的 OR 值更高〔女性： OR=1.58,95%CI(1.14,2.18); 男性： OR=1.41,95%CI(1.07,1.86)〕。 结论 糖 尿病与食管癌存在关联，提示糖尿病可能是食管癌的一个独立致病危险因素。 【关键词】 食管肿瘤；糖尿病；病例对照研究；危险因素； Meta 分析 【中图分类号】 R735.1 R587.1 【文献标识码】 A doi:10.3969/j. issn.1007-9572.2013.01.092 Association between Diabetes Mellitus and Esophageal Cancer: A Meta- analysis of Case - control Studies SHI Yi - hai, HOU Li-ying, QIU Jiong -liang.Shanghai Pudong New Area Gongli Hospital, Shanghai 200135,China 【Abstract] Objective To evaluate the association between diabetes mellitus(DM)and esophageal cancer(EC). Methods We searched in CNKI, CBM,VIP,Cochrane Library,PubMed, EMbase and Ovid, etc. from databases establish- ment to April 2012 with the following key words; esophageal cancer, esophageal neoplasms, and diabetes mellitus. All the case - control studies on the association between DM and EC were included and the quality of them was assessed. Meta - analysis was conducted using the Cochrane Collaborations RevMan 5.0 software. Results A total of 6 case -control studies were included, with 1553 cases in case group and 57767 cases in control group. The DM patients in the two groups were 139 cases and 2294 ca- ses respectively. Meta analysis showed that there was statistical heterogeneity among studies〔OR =1.60,95% CI(1. 13, 2.26) 〕.Sub-group analysis showed that regardless of sex, the incidence of DM in case group was higher than in control group, and the OR