MDL-27032-生命科学试剂-MCE.pdfVIP

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MDL27032

Cat.No.:HY-105517

CASNo.:110124-55-5

分⼦式:C₁₁H₁₂N₂O₂

分⼦量:204.23

作⽤靶点:PKC;PKA

作⽤通路:Epigenetics;TGF-beta/Smad;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MDL27032是⼀种作⽤于活性位点的蛋⽩激酶C(PKC)和cAMP依赖性蛋⽩激酶(PKA)抑制剂，其Ki值分别为

24μM和14.3μM。MDL27032能够松弛⾎管平滑肌，可⽤作⾎管扩张剂[1]。

REFERENCES

[1].RobinsonPJ,etal.MDL27,032[4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone],anactivesite-directedinhibitorofproteinkinaseCand

cyclicAMP-dependentproteinkinasethatrelaxesvascularsmoothmuscle[J].TheJournalofpharmacologyandexperimentaltherapeutics,

1990,255(3):1392-1398.

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1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤