NS1652-Standard-生命科学试剂-MCE.pdfVIP

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NS1652(Standard)

Cat.No.:HY-100244R

CASNo.:1566-81-0

分⼦式:C₁₅H₁₁F₃N₂O₃

分⼦量:324.25

作⽤靶点:ChlorideChannel;ReferenceStandards

作⽤通路:MembraneTransporter/IonChannel;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NS1652(Standard)是NS1652(HY-100244)的分析标准品。本产品⽤于研究及分析应⽤。NS1652是⼀种可逆

的阴离⼦电导(anionconductance)抑制剂，在⼈和⼩⿏的红细胞中，可以抑制氯离⼦通道(chloride

channel)，IC50值为1.6μM。

IC50TargetIC50:1.6μM(chloridechannel,humanandmouseredbloodcell)[1]

REFERENCES

[1].KjaerK,etal.ChloridechannelblockersinhibitiNOSexpressionandNOproductioninIFNgamma-stimulatedmicroglialBV2cells.Brain

Res.2009Jul24;1281:15-24.

[2].BennekouP,etal.VolumecontrolinsicklecellsisfacilitatedbythenovelanionconductanceinhibitorNS1652.Blood.2000Mar

1;95(5):1842-8.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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