术前放疗对子宫颈癌患者血清ⅦGF、scc—Ag的影响.pdfVIP

2011年9月第49卷第25期 ·临床研究 · 术前放疗对子宫颈癌患者血清ⅦGF、scc—Ag的影响 陆安娜 (武警浙江总队杭州医院肿瘤科，浙江杭州310051) 【摘要 】目的 探讨子宫颈癌患者手术治疗前放疗对血清血管内皮生长因子(VEGF)、鳞状细胞癌抗原(SCC—Ag)水平的 影响。方法 选择我院肿瘤科子宫颈癌患者65例，随机分为观察组(33例)和对照组(32例)，对照组行单纯手术治疗 ，观 察组在手术前进行放疗，对 比分析两组患者治疗前后的血清VEGF、SCC—Ag变化及近期预后情况。结果观察组和对照 组术后血清VEGF、SCC—Ag含量均较治疗前降低，差异有统计学意义(P0．05或P0．O1)，且观察组优于对照组(P 0．05)；观察组近期生存率为90．91％，优于对照组的71．88％ (P0．05)，但两组之间并发症发生率差异无统计学意 义(P0．05o 结论术前放疗可明显降低子宫颈癌患者血清 VEGF、SCC—Ag水平，且预后较好。 [关键词 】子宫颈癌 ；放射治疗；手术 ；血管内皮生长因子；鳞状细胞癌抗原 [中图分类号 】R734．2 【文献标识码 】B 【文章编号 】1673—9701(2011)25—73—02 Effects ofPreoperatiVe Radi0therapy for Serum VEGF，SCC—Ag in PatientswithCarcinomaofUterineCervix LUAru1a OncologyDepartmentofHangzhouHospitalAttachedArmedPoliceinZhejiangProvince，Hangzhou，310051，China A【bstract】ObjectiveToexploretheeffectsofpreoperativeradiotherapyforserum vascularendothelialgrowthfactor(VEGF)， squamouscellcarcinomaantigen(SCC-Ag)inpatientswithcarcinomaofuterinecervix．MethodsAll65caseswithcarcinomaof uterinecervixinoncologydepartmentofourhospitalwererandomlydividedintoobservationgroup(33cases)andcontrolgroup(32 cases)．Thecontrolgrouptreatedonlywithoperation．Theobservationgrouptreatedwithpreoperativeradiotherapy．Comparativeanalysis theserum VEGF，SCC—Agoftwogrouppatientsbeforeandaftertreatment．ResultsTheserum VEGF，SCC-Agoftwogroupsafter operationweredeclinethanpretherapy，andwasstatisticallysignificantdifference(P O．05orP 0．01)．Theobservationgroup wasbetterthancontrolgroup (P 0．05)．Therecentsurvivalrateinobservationgroupwas90．91％whichwasbetterthan71．88％ incohtrolgroup (P 0．05)．Therewasnosignificantdifferenceforcomplicationinthesetwogroups(P 0．05)．Conclusion Preoperativeradiotherapycanclearreducethelevelofserum VEGF，SCC—Aginpatientswithcarcinomaofuterinecervix，andthe prognosisiswel1． K【eywordslCarcinoma