疏肝活血养阴法配合盐酸氯西汀治疗系统性红斑狼疮合并抑郁障碍临床研究.DOCVIP

临床医学论文-疏肝活血养阴法配合盐酸氯西汀治疗系统性红斑狼疮合并抑郁障碍临床研究 ?????????? 作者：谭莲蓉 余俊文 郑宝林 【摘要】? 　　目的 探讨疏肝活血养阴法治疗系统性红斑狼疮合并抑郁障碍的临床疗效。方法 系统性红斑狼疮合并抑郁障碍患者70例，随机分为2组，各35例。对照组予盐酸氯西汀20 mg，每日1次口服。治疗组在对照组基础上加用疏肝活血养阴中药。7周为1个疗程，1个疗程后观察2组治疗前后抑郁症状改善情况及临床疗效。结果 治疗组总有效率97.0%，对照组总有效率88.0%,2组总有效率比较差异有统计学意义(P＜0.05)。2组治疗后抑郁评分比较差异有统计学意义（P＜0.05)。结论 疏肝活血养阴法配合盐酸氯西汀治疗系统性红斑狼疮合并抑郁障碍比单纯盐酸氯西汀治疗疗效显著。 【关键词】? 系统性红斑狼疮 抑郁症 疏肝活血养阴法 　　Clinical observation on the therapeutic effect of Shuganhuoxueyangyin therapy on systemic lupus erythematosus complicated with depression disorder ??? 　　【Abstract】? Objective? To observe the therapeutic effect of Shuganhuoxueyangyin therapy on systemic lupus erythematosus complicated with depression disorder. Methods? 70 patients with systemic lupus erythematosus complicated by depression disorder were randomly divided into two groups.35 patients in control group were treated by fluoxetine hydrochloride 20 mg once a day; the other 35 patients in treatment group, on the basis of control group, were treated by Shuganhuoxueyangyin medicine, with a treatment course of 7 weeks for both groups. The therapeutic effect and the state of improvement of depression symptoms were observed before and after the treatment. Results?The total effective rate in treatment group was 97.0%,which was 88.0% in control group，there was a significant difference in the therapeutic effect and depression scoring between two groups(P0.05). Conclusion? Shuganhuoxueyangyin therapy is effective in treating systemic lupus erythematosus complicated with depression disorder.??? 　　【Key words】? Systemic lupus erythematosus; Depression disorder;Shuganhuoxueyangyin therapy 　　2005-06—2007-06，我们采用疏肝活血养阴法配合盐酸氯西汀治疗系统性红斑狼疮(systemic lupus erythematosus，SLE)合并抑郁障碍35例，并与单纯盐酸氯西汀治疗35例对照观察，现报告如下。 　　1? 资料与方法 　　1.1? 一般资料? 全部70例均为我院内科门诊患者，随机分为2组。治疗组35例，年龄18～40岁，平均29岁；病程3个月～12年，平均5年。对照组35例，年龄20～39岁，平均30岁；病程5个月～10年，平均6年。2组病例一般资料比较差异无统计学意义（P0.05），具有可比性。 　　1.2? 诊断标准? SLE的诊断参照美国风湿病学会1982年修订的SLE分类标准［1］确诊，排除合并尿毒症、妊娠或哺乳期患者。抑郁障碍诊断按《中国精神疾病分类方案与诊断标准》［2］