肿瘤患者血清中Neu5Aca2-6Gal糖链序列的多糖分子表达的研究.pdfVIP

基l尘摹世界冷冻鹁安盎垒量蔓蓦量生蟹胂麓靶向{篷疽大盒 肿瘤患者血清中Neu5Aca2-6Gal糖链序列的多糖分子表达的研究 邹宁1，温居一2，孙海3，张积仁‘ 作者单位1．南方医科人学附属珠江医院肿瘤中心2．海军总医院放射肿瘤科3．南京军区总医院肿瘤科 血清中的表达规律。方法应用SNA(接骨小凝集素)亲和层析法从正常人血清中获得SNA识别的 例良性疾病患者和240例正常人血清进行检测。结果肺癌、结直肠癌患者血清中SNA识别的多糖分子明 显高于正常人和良性疾病患者，阳性率分别为64．5％，59．5％，鼻咽癌和肝癌患者的阳性率分别为14．3 ％，21．7％。且在肺癌和结直肠癌患者有效治疗后该多糖分子水平显著下降，刚性率也_卜．降。结论血清 并可为临床诊断和治疗效果的评价提供参考指标。 关键词SNA多糖肿瘤 inSerum Tumors of oftheNeu5Aca2—6GalRelated of InvestigationExpression PolysaccharideMalignant Patients ZOU Ji-renl． Hal3，ZHANG Nin91，WENJu．yi2，SUN Affiliatedto Medical 10282，China．； 1．0ncologyCenter,ZhujiangHospital Nanfang University,Guangzhou，5 ofRadiation General of General Oncology,Nanjing 2．Department Oncology,NavyHospital．：3．Department Command Hospital．ofNanjingMilitary Todetectthe oftheNeu5Aca2—6Galrelated inserumof Abstraet：Objecfiveexpression polysaccharide liver cancerand cancer TheSNA· nasopharyngeal cancer,colorectallung patients．Methods carcinoma,primary Neu5Aca2—6Galwas identifying glycoproteinacquiredbySNA(SambucusNigraLectin)affinity methodfromnormal serumandWasmarkedthehorseradish 33tumor benign person by peroxidase．1patients，64 disease and240normal serumsweredetectedthesubtractionof The patients person by agglutinin．Results leveloftheSNAidentificationinserumof cancerandcolorectalCanCelWasobvious polysaccharide lung higher than itinnormal and disease r