HIV Cure and HIV Reservoirs.pdfVIP

478 BiomedEnvironSci，2014；27(6)：478—480 ResearchHighlight HIV CureandHIV Reservoirs YINQianQian，ShaoYiMing，andMALiYing ThesuccessofcombinedantiretroviraItherapy HfV Persistence． Reservoirs and Eradication (cART) has dramaticaIIy improved the cIinicaI Strategies． outcomesofHIV infectionandmadeHIV infectiona ViraIreservoirsstiIIremainamajorobstacleto chronic disease．NOnetheIess，cART alone cannot the HIV cure．Through the failure ofthe Boston elimihateviralreservoirsandfuIlyrecoverpatients patients．wehavediscoveredthatHlV reservoiris health， so the patients have to receive this deeper and more persistentthan whatwe had treatmentforIifetime．Therefore．researchershave known previously and current HIV detection focusedtheire仟ortsonthecureforHlV infection．In techniquesmaynotbesu仟icient．HIVpersistenceis recentyears，some intriguing and insplrlng cases thoughtto stem primar-lYfrOm the presence of indicatedthatthecureofHIVinfection(HIVcure)or integrated proviralgenomewithin long—lived cells durable alleviation ofHIV infection maynotbea which areJikelyto harborJatentprovirus．Resting dream anymore．BerlinPatient M ississiPPiBaby． memOrv CD4 T cells are the best．characterized andprobably LongBeachBaby havebroughtgreat reservoirsofIatentHIV Josefsson eta1． found hopetotheHIV cure．Manyscientistsbelievethat that persistent HIV一1 in peripheraI blood and theHIVcureisiustaquestionoftime． gut—associatedlymphoidtissue(GALT)ismainlyin Now novelapproachesto cure HIV jnfection memoryCD4 Tcellsandindicatedthatpersistence whichcanbypasstheIimitationsofcurrenttherapies of a remarkably stable population of infected andrecoverpatientsheaftharebeingexplored： mem0rycell