固体脂质纳米粒经皮给药地研究进展.pdfVIP

固体脂质纳米粒经皮给药的研究进展 1，2 3 3 4 张涛 ，刘翠 ，黄华 ，张雁翎 （1. 重庆医药工业研究院有限责任公司，重庆 400061 ；2.重庆市化学制药工 程技术研究中心，重庆 400061 ；3.重庆医科大学药学院药剂学教研室，重庆 400016 ；四川大学华西药学院，成都，610041 ） 摘要：经皮给药系统研究是药剂学研究的重点和难点领域，众多学者致力于 这方面的研究，以达到治疗水平上的经皮和黏膜透过量。研究脂质体、微乳 及固体脂质纳米粒等药物载体是经皮给药系统研究的药剂学重点领域之一。 本文查阅国内外文献，就固体脂质纳米粒作为经皮给药载体、制备方法和经 皮给药特点、促进药物透过皮肤的机理及其经皮渗透动力学及药效学做出分 析和总结。固体脂质纳米粒在经皮给药系统展现良好前景。 关键词：经皮给药系统,固体脂质纳米粒,综述 Recent Advances of Solid lipid nanoparticles in Transdermal Drug Delivery System 1，2 3 3 4 ZHANG Tao , LIU Cui , HUANG Hua ,ZHANG Yanlin （1. Chongqing Pharmaceutical Research Institute CO.,LTD, Chongqing 400016; 2. Chongqing Chemical Pharmacy Enginering Research Center , Chongqing 400061 ： 3. College of Pharmaceutics, Chongqing Medical Sciences University, Chongqing 400016; West China School of Pharmacy, Sichuan University, Chengdu, 610041） Abstract ：The research of Solid lipid nanoparticles in transdermal drug delivery system always is a crucial and difficult field in pharmaceutics research，studies have been carried out to increase the drug permeability through skin and mucous membrane, to achieve therapeutic levels. The research of liposomes,microemulsion and solid lipid nanoparticles as drug carrier is one of the key areas of pharmacy in transdermal drug delivery system.Solid lipid nanoparticles as transdermal drug delivery carrieris, characteristics and preparation is analysised and summarized in this article for the mechanism of through skin, percutaneous penetration kinetics and pharmacodynamics ，through referring to domestic and foreign literatures. Solid lipid nanoparticles show good prospects in transdermal drug delive