他汀类降脂药对急慢性脑血管病的远期疗效及卒中再发风险的影响.docVIP

他汀类降脂药对急慢性脑血管病的远期疗效及卒中再发风险的影响 　　[摘要] 目的 观察他汀类降脂药对急慢性脑血管病的远期疗效及卒中再发风险的影响。 方法 选取2009年5月～2010年5月我院就诊的急慢性脑血管病患者215例，随机分为研究组107例及对照组108例，观察IMT及动脉粥样硬化斑块面积的变化及血脂改变、心脑血管不良事件发生情况。 结果 治疗组患者治疗后与对照组TG、TC、LDL-C及HDL-C比较，差异有统计学意义（P0.05）。两组患者12、18、24个月时两组IMT值比较，差异有统计学意义（P0.05）；对所有患者随访2年，研究组致死性脑卒中、非致死性脑卒中、冠状动脉事件发生率及死亡率皆显著低于对照组，两组比较，差异有统计学意义（P0.05）。 结论 阿托伐他汀安全、有效、耐受性好，不良反应少，可作为伴有颈动脉粥样硬化患者的常规用药。 　　[关键词] 他汀类降脂药；急慢性脑血管病；卒中；再发风险 　　[中图分类号] R743 [文献标识码] A [文章编号] 2095-0616（2013）24-55-03 　　Effects of long term curative effect on acute and chronic cerebral vascular disease and stroke， statins recurrence risk 　　CHEN Chunlei1 QIU Zhihui2 SU Shixin3 ZHANG Guoliang4 　　1.Department of Neurology， the Second Hospital of Nanan City， Nanan 362300， China；2.Department of Internal Medicine， the Third Peoples Hospital of Shenzhen， Shenzhen 518000，China； 3.Department of Internal Medicine， Nanan Hospital， Nanan 362300， China； 4.Institute of Liver Disease， the Third Peoples Hospital of Shenzhen， Shenzhen 518000， China 　　[Abstract] Objective To evaluate the effects of long term curative effect on acute and chronic cerebral vascular disease and stroke， statins recurrence risk. Methods 215 of acute and chronic cerebral vascular disease patients cases were all collected from May 2009 to May 2010 in our hospital， who were randomly divided into study group 107 cases and control group of 108 patients， all patients were followed up for 2 years， （IMT） changes and blood lipids， atherosclerosis plaque area change and cardiovascular adverse events were all observed. Results Compared two groups of patients with TG， TC， LDL-C and HDL-C after treatment， the diference was signarant（P0.05）. The change of IMT in 12， 18， 24 months of two groups of IMT value comparison， the diference was signarant（P0.05）； The study group of fatal stroke，nonfatal stroke， the incidence of coronary events and mortality were significantly lower than those in the control group （P0.05）. Conclusion Atorvastatin has safe， effective， well tolerat