甲泼尼龙冲击递减疗法治疗重症过敏性紫癜的效果观察.docVIP

甲泼尼龙冲击递减疗法治疗重症过敏性紫癜的效果观察 　　[摘要] 目的 探讨甲泼尼龙冲击递减疗法治疗重症过敏性紫癜的临床效果。 方法 选取本院2010年9月～2013年9月收治的60例重症过敏性紫癜患者为研究对象，将其随机分成A组与B组，各30例。A组患者给予甲泼尼龙冲击疗法治疗，病情改善后改为口服递减治疗，B组患者给予甲泼尼龙常规治疗，观察两组患者的临床治疗效果。 结果 A组患者的皮疹消退时间为（6.86±3.25）d，腹泻缓解时间为（3.07±1.97）d，消化道出血消退时间为（3.76±2.56）d，肾损害恢复时间为（7.81±1.83）d，明显较B组患者的皮疹消退时间[（8.13±2.82）d]、腹泻缓解时间[（4.50±1.87）d]、消化道出血消退时间[（6.50±2.28）d]、肾损害恢复时间[（9.81±2.33）d]缩短（P0.05）；两组患者治疗后其白介素-6（IL-6）、IL-8等均较治疗前有所改善且A组改善较B组明显（P0.05）。 结论 甲泼尼龙冲击递减疗法治疗重症过敏性紫癜的临床效果较显著，其能有效改善患者的临床症状，具有较好的减轻肾脏损害的作用，值得推广应用。 　　[关键词] 甲泼尼龙；冲击疗法；递减；重症过敏性紫癜 　　[中图分类号] R554+.6 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0075-03 　　[Abstract] Objective To investigate the clinical effect of methylprednisolone pulse diminishing therapy in the treatment of severe allergic purpura. Methods 60 patients with severe allergic purpura admitted to our hospital from September 2010 to September 2013 were selected as the study subjects and randomly divided into the group A （n=30）and the group B （n=30）.The group A received methylprednisolone pulse therapy and changed to oral diminishing treatment when the state of illness improved.The group B received conventional methylprednisolone treatment.The clinical treatment effect of the two groups was observed. Results The deflorescence time，diarrhea remission time，gastrointestinal bleeding vanishing time and renal damage recovery time of the group A was （6.86±3.25） days，（3.07±1.97） days，（3.76±2.56） days and （7.81±1.83） days respectively which were significantly shorter than the （8.13 ± 2.82） days，（4.50 ± 1.87） days，（6.50 ± 2.28） days and （9.81 ± 2.33） days of the group B （P0.05）；after treatment，interleukin-6 （IL-6） and IL-8 of both groups improved compared to those before treatment （P0.05） and the group A was improved obviously compared to the group （P0.05）. Conclusion Methylprednisolone pulse diminishing therapy shows more significant clinical effect in the treatment of severe allergic purpura and can effectively improve the patients′ clinical symptom，and alleviate rena