曲美他嗪治疗冠心病合并左心功能不全患者疗效及药理机制分析.docVIP

曲美他嗪治疗冠心病合并左心功能不全患者疗效及药理机制分析 　　doi：10.3969/j.issn.1007-614x.2014.21.12 　　摘 要 目的：研究分析曲美他嗪用于冠心病伴有左心功能不全的治疗效果。方法：2013年1月-2014年3月收治冠心病合并左心功能不全患者44例，按照入院挂号的单双码将其分成观察组与对照组，对照组22例采取常规方法治疗；观察组22例在常规方法治疗的同时加用曲美他嗪进行治疗。结果：两组左室壁运动评分、LVEF、左室收缩末内径、左室舒张末内径等均较治疗前有所改善，但观察组改善的更为显著，差异有统计学意义（P0.05）。结论：曲美他嗪用于冠心病合并左心室功能不全的治疗获得了良好的效果，使心肌射血分数有所提高，在临床中的实用性、可推行性较强。 　　关键词 曲美他嗪 冠心病合并左心室功能不全 疗效 药理机制 　　Analysis of curative effect and pharmacological mechanism of trimetazidine in the treatment of coronary heart disease patients with left cardiac insufficiency 　　Qi Jianmin 　　The First Department of Internal Medicine，the Peoples Hospital of Shilin County， Kunming City，Yunnan 652200 　　Abstract Objective：To study and analyze the treatment effect of trimetazidine for coronary heart disease combined with left cardiac insufficiency.Methods：44 coronary heart disease patients with left cardiac insufficiency were selected from January 2013 to March 2014.In accordance with the admission registration of single and double code，they were divided into the observation group and the control group.22 cases in the control group were treated with routine treatment.22 cases in the treatment group were treated with trimetazidine at the same time of routine treatment.Results：After treatment，the left ventricular arm movement score，LVEF，left ventricular end systolic dimension，left ventricular end diastolic dimension of two groups were improved than those before treatment.The improvement of observation group was more significantly，and the difference was statistically significant（P0.05）.Conclusion：Trimetazidine in the treatment of coronary heart disease combined with left cardiac insufficiency has good effect，It can improves cardiac ejection fraction.Its practicability and feasibility are strong in the clinical. 　　Key words Trimetazidine；Coronary heart disease combined with left cardiac insufficiency；Curative effect；Pharmacological mechanism 　　冠心病是心血管内科临床常见的一种疾病，一般伴有左心功能不全[1]。曲美他嗪治疗由于急性或慢性心肌缺血导致的心功能不全具有良好的效果，能