Flavonoid compound capsule long-term toxicity study in rats.docVIP

 PAGE \* MERGEFORMAT 13 Flavonoid compound capsule long-term toxicity study in rats Author: Hong-Ping Pan Wei Hua-Ling Chen Ying [Abstract] Objective To observe the flavonoid compound capsule on a long-term toxicity test in rats the effects. Methods flavonoid compound capsule 20.75,4.15 mg / kg (for the clinical daily dose of 50 times and 10 times) to rats fed with a continuous 13 weeks, withdrawal 2 weeks, body weight were measured to calculate organ coefficient of determination of hematology and blood biochemical indicators and for histopathological examination. Results of compound flavone capsules high-and low-dose group of rats the appearance of signs, behavioral activity, body weight, organ coefficient, hematology and blood biochemical indicators, with the blank control group, no significant differences; pathological examination and no drug toxicity related to the obvious lesions seen after discontinuation of drug of delayed toxicity. Conclusion The compound flavone capsules in rats had no significant long-term drug toxicity, the clinical inference to be dose should be safe. [Keywords:] compound flavone capsules long-term toxicity test in rats Abstract: ObjectiveTo observe the effects of Compound Flavone capsules on the rat chronic toxicity test.Methods 60 rats were randomly divided into 3 groups, each group was given Compound Flavone capsules intragastrically in dose of 20.75, 4.15 mg / kg (50 and 10 times of clinic dose) for 13 weeks. Half of the animals were killed immediately after the last dose, and another half of rats were observed for 2 weeks after medicine withdraw. Parameters examined included general condition, body weight, food intake, blood cell, blood biochemistry , organ index, and histopathological exmination.ResultsThe outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by comparing with control group.The pathological examination did not discover