NFκBp65 and in ICAM1 expression in thyroid tumors and correlation analysis.doc

 PAGE \* MERGEFORMAT 11 NFκBp65 and in ICAM1 expression in thyroid tumors and correlation analysis Author: Hong-Mei Yu-Ju CHOI Chun Zhu Shi-Qing Chen Abstract of NF  κBp65 and ICAM  1 in thyroid tumors and correlation analysis. Methods: The People’s Hospital of Wuhan University and the Shiyan City Taihe Hospital, Department of Pathology from 1999 to 2004 archived wax blocks of 40 cases were diagnosed after surgical resection of thyroid tumors specifically, of which 20 males and 20 female, aged 23 ~ 71 years old (average 43.8 years); according to WHO histologic classification criteria: papillary carcinoma (PTC) 12 cases of follicular carcinoma (FTC) 10 cases of medullary carcinoma (MTC) 10 cases of undifferentiated carcinoma (UTC) 8 cases; in accordance with standard clinical and pathological AJCC staging: Ⅰ period of 12 cases, Ⅱ period of 10 cases, Ⅲ 11 cases, Ⅳ period of 7 cases. At the same time take 15 cases of thyroid tumor tissues and normal thyroid tissue in 5 cases as controls. Patients with preoperative radiotherapy or chemotherapy were not. Using histological and immunohistochemical S  P method, respectively papillary carcinoma, follicular adenocarcinoma, medullary carcinoma, undifferentiated carcinoma, thyroid tumor tissue and normal thyroid tissue adjacent to the histological structural changes in the relevant NF  κBp65 factor and ICAM  1 was observed using HPIAS  2000 image analysis system measured NF  κBp65 and ICAM  1 expression in the above groups, the average optical density and the average positive area ratio. Results: NFvκB p65 and ICAM  1 in papillary carcinoma, follicular adenocarcinoma, medullary carcinoma, undifferentiated cancer cells with strong expression in cytoplasm; NF  κB p65 and ICAM  1 in the thyroid tumor tissues expressed very weak or no expression; NF  κB p65 and ICAM  1 in normal thyroid tissue expressed very weak or no expression. The single-factor analysis of variance, the difference between the gro