On clozapine and ziprasidone on the electrocardiogram.docVIP

 PAGE \* MERGEFORMAT 9 On clozapine and ziprasidone on the electrocardiogram [Abstract] Objective To investigate the properties of typical antipsychotics and atypical antipsychotics clozapine and ziprasidone in patients with schizophrenia ECG QTc interval and heart rate. Methods 53 cases of 52 patients taking clozapine and Qi Rasi ketones ECG QTc interval in patients with schizophrenia and heart rate were compared, and the results were analyzed. Results at 4 weeks after treatment QTc interval clozapine group average of 423.25 + -33.40, ziprasidone QTc interval average 396.15 + -56.23, compared to differences between the two (P lt;0.05, two groups of patients with prolonged medication was no statistical significance. and can be seen after administration of ziprasidone 15 times the average heart rate / min, compared with before treatment differences (P lt;0.05. Conclusion Early administration of clozapine on the ECG QTc interval of greater than ziprasidone, patients with slow heart rate based on ziprasidone should pay attention to heart rate change. [Keywords:] clozapine and ziprasidone ECG QTc interval Clozapine is effective as typical antipsychotics and has been widely used clinically, there are many reports of its side effects, which cause prolonged QTc may occur torsades arrhythmias, sudden death led to an important reason for patients [1] , ziprasidone as a new type of atypical antipsychotics, relatively few side effects, for the cause ECG changes reported QTc interval is not much, now I’m taking clozapine and ziprasidone hospital Schizophrenia A total of 105 cases of patients with ECG QTc interval and heart rate compared to Dr. Yu Linchuang safe and effective drugs provide the scientific theoretical basis for selection to avoid adverse reactions, the results are as follows. 1 Materials and Methods 1.1 Clinical data 1.1.1 Selection criteria selected in October 2008 -2010 in March in our hospital psychiatric in-patient taking clozapin