Panax notoginseng saponins on hypoxia and hypercapnia effects of pulmonary vasoconstriction.docVIP

 PAGE \* MERGEFORMAT 16 Panax notoginseng saponins on hypoxia and hypercapnia effects of pulmonary vasoconstriction [Abstract] Objective: To investigate the Panax notoginseng saponins (PNS) on pulmonary artery smooth muscle relaxing effect and its relationship with the relationship between the pulmonary artery endothelial cells. Methods: Rat aortic rings isolated lung perfusion model. Normoxia and hypoxia at high carbon dioxide conditions, observe the PNS of potassium chloride (KCl) and norepinephrine (NE) precontracted endothelium intact blood vessels and vasodilation to the endothelium of blood vessels. Results: ① in normoxia and hypoxia-hypercapnia conditions, the cumulative concentration of PNS on the 60 mmol / L KCl, and 10-5 mol / L NE pre-contraction of vascular rings are produced dose-dependent vasodilation (P amp;lt;0.05). ② hypoxia and hypercapnia enhanced the role of PNS pulmonary vasodilation, with the corresponding concentration compared with the normoxic group, have statistically significant (P amp;lt;0.05 or P amp;lt;0.01). ③ normal oxygen conditions, the existence of endothelium group compared with the endothelium, PNS vasodilation effect of no significant difference (Pamp;gt; 0.05); but under the conditions of hypoxia and hypercapnia to endothelial vasodilatory effect of PNS group much larger than the endothelial integrity group (P amp;lt;0.05 or P amp;lt;0.01). Conclusion: PNS reduce the hypoxic hypercapnic pulmonary vasoconstriction, and after removal of pulmonary artery endothelial this role more evident, its mechanism may be related to the role of endothelium-mediated loss related. [Keywords:] panax notoginseng hypoxic hypercapnic blood endothelial cells Abstract: Objective: To investigate the effect of Panax notogino side (PNS) on the main pulmonary artery rings and the underlying mechanisms involving in the role of endothelial cell. Methods: The model of isolated rat pulmonary artery rings in organ baths was performed. Under normoxi