Scutellarin right right paracetamol and LPS-induced liver injury and mortality rate of.docVIP

 PAGE \* MERGEFORMAT 7 Scutellarin right right paracetamol and LPS-induced liver injury and mortality rate of [Abstract] Objective To observe the scutellarin right right paracetamol and LPS-induced liver injury and mortality rates. Methods to different models of mice fed for scutellarin 25 ~ 500 mg * kg-1, 1 time / d. 7 ~ 14 d after the single intraperitoneal injection of different doses of paracetamol and LPS, the mice died of liver function changes and. The results of small doses of scutellarin does not affect the acetaminophen-induced liver injury, but increased dose in mice was significantly higher mortality rate; small doses scutellarin can significantly increase the LPS-induced liver damage, a marked increase in LPS-induced mortality in mice. Conclusion scutellarin treatment of heart or cerebral vascular diseases, infectious diseases when a patient encounter, we should note that the use of scutellarin dose scutellarin may be aggravated by the improper use of lipopolysaccharide (LPS)-induced liver injury; the use of paracetamol treatment of various diseases caused by heat, the combination scutellarin also pay attention to the use of Scutellarin Dose. [Keywords:] scutellarin acetaminophen liver injury in lipopolysaccharide-fatality rate Scutellarin (scutellarin), also known as scutellarin is Compositae Erigeron breviscapus dry the whole plant (Erigeron), the flavonoids extracted from the active ingredients [1]. Scutellarin with increased blood flow, improve microcirculation and dilation of blood vessels, reducing blood viscosity, blood fat, and promote fibrinolysis, anti-thrombotic, anti-platelet aggregation and other effects in clinical practice has been widely used in cerebral thrombosis, coronary heart disease angina pectoris such as ischemic cardiovascular and cerebrovascular diseases [1]. Another large number of studies have shown that a variety of flavonoid compounds on experimental liver injury models have the protective effect [2]. We scutellari