Scutellarin improve dexamethasone-induced insulin resistance study.docVIP

 PAGE \* MERGEFORMAT 5 Scutellarin improve dexamethasone-induced insulin resistance study Author: Liu Shu Ling Wang Nai-ping Xiufen [Abstract] Objective To observe the scutellarin right dexamethasone (DEX)-induced insulin resistance (IR) in rats and its mechanism. Method of intramuscular injection of DEX-induced IR, while ig scutellarin treated rats were detected by fasting blood glucose (FBG), fasting serum insulin (FINS), serum total cholesterol (TC), triglyceride (TG), a nitric oxide (NO) levels. Results scutellarin can significantly reduce the DEX-induced IR in rats FBG, FINS levels, increased insulin sensitivity index (ISI), lower TC levels, the elevated TG have a certain inhibitory effect, can increase serum NO concentration. Conclusion scutellarin can improve the DEX-induced insulin resistance, its mechanism and improving glucose and lipid metabolism disorders, improve insulin sensitivity, elevated serum NO content of the. [Keywords:] scutellarin; insulin resistance; dexamethasone; therapeutic effect Insulin resistance (insulin resistance, IR) is a prevalent human disease, a phenomenon, it is often associated with type 2 diabetes, obesity, hypertension, atherosclerosis, coronary heart disease and other co-exist. Scutellarin (scutellarin, Scu), also known as scutellarin, the chemical known as 4,5,6 - trihydroxy flavonoid glycosides -7 gluconic acid, is widely used in the treatment of ischemic cardiovascular and cerebrovascular diseases, Chinese medicine formulations Dengzhanhua Su’s main active ingredient (content of 90% and above). Pharmacological studies have shown that it can inhibit the protein kinase strong C [1]. Experimental studies have shown that scutellarin type 1 diabetic rat liver, kidney, thoracic aorta, retina diseases has a protective effect [2 ~ 5]. Clinical studies have shown that scutellarin can improve insulin sensitivity index in patients with coronary heart disease, improve lipid metabolism [6]. I early studies have shown that scu