SD of felodipine on the morphology of bone tissue.docVIP

 PAGE \* MERGEFORMAT 8 SD of felodipine on the morphology of bone tissue Study: Song Jinhui, Chen Jun, Wang Weizhuo, Zou spring, Yanhong Wei, Kun-Zheng [Abstract] clarity of purpose felodipine feeding on bone metabolism in SD rats, to determine the impact of osteoporosis, the clinical use of animal experiments provide direct evidence. Methods 132 SD rats were randomly divided into control felodipine group and the high, middle and end of dose group. the control group given distilled water per day, felodipine high, medium and low dose group were given daily felodipine 0.15,0.45,1.25 mg / kg body weight ig .3,4,5,6 right femur length of months after HE staining, calculate the average trabecular bone density (MTPD), mean trabecular plate separation (MTPS), mean trabecular thickness (MTPT), trabecular connection between the points (TB.n), the number of trabecular bone at the end (FFT) and other static parameters. Results 3,4 months later, the rats showed no difference between these indices (Pgt; 0.05), 5 months after felodipine and high dose group and control group and the low dose group MTPD, MTPT, TB.n significantly lower (P lt;0.05), MTPS, FFT was significantly increased (P lt;0.05), 6 months after low dose of felodipine compared with other groups, MTPD, MTPT, TB.n increased significantly (P lt;0.05), MTPS, FFT significantly reduced (P lt;0.05), but not felodipine and high dose group normal group, MTPD, MTPT, TB.n were significantly reduced (P lt;0.05), MTPS, FFT significantly increased, particularly high-dose group (P lt;0.05, P lt;0.01). Conclusion felodipine in rats with short-term no effect on the histological structure of the femur. With treatment time, in high doses can cause bone loss, low dose can inhibit bone resorption, which will help to increase bone strength, direction, effectively protect bones. [Keywords:] felodipine, bone tissue morphology, rats, bone metabolism, osteoporosis ABSTRACT: Objective To investigate the effects of felodip