The mechanism of renal fibrosis and the relationship between high blood pressure.docVIP

 PAGE \* MERGEFORMAT 19 The mechanism of renal fibrosis and the relationship between high blood pressure [Keywords:] kidney disease Kidney disease and hypertension close ties. Kidney disease can cause high blood pressure, high blood pressure can cause kidney disease. 6th International Symposium on Hypertension and Related Diseases proposed show: in major cities nationwide prevalence rate of hypertension was 15%. About 160 million hypertension patients in China. Clinically, 90% of renal failure patients have high blood pressure combined. Over the past 10 years, the United States end-stage renal disease (ESRD) incidence rate of about 9% growth rate per year, in which new cases of ESRD caused by hypertension, 28% [1]. Renal fibrosis is a chronic kidney disease develop the final result is one of the factors leading to ESRD. Of renal fibrosis and hypertension reinforce each other, if unchecked, will be a vicious circle. Therefore, to reduce renal fibrosis, control high blood pressure, to break this vicious cycle is a treatment of end-stage renal disease and high blood pressure essential. This paper will address the pathogenesis of renal fibrosis and its relationship with the relationship between high blood pressure. A formation mechanism of renal fibrosis 1.1 The occurrence of renal fibrosis in the process of renal fibrosis is currently considered the development process can be divided into four stages [2]. The first stage is cell activation and injury, inflammation, injury caused by the activation of renal tubular epithelial cells in interstitial monocyte - macrophage infiltration; second stage is to promote the release of fibrotic factors, including cytokines, growth factors, Vascular adhesion-activating factor and chemotactic factor; The third stage is the formation of fibrosis, showed an increase in matrix protein synthesis, degradation reduced, leading to matrix proteins in renal interstitial deposition; fourth stage is the structure and function of kidney