Transforming growth factor β1 and fibrosis in Progress in Liver.docVIP

 PAGE \* MERGEFORMAT 14 Transforming growth factor β1 and fibrosis in Progress in Liver [Abstract] transforming growth factor β1 (TGF-β1) is a polypeptide growth factor family member, can regulate cell growth and differentiation, it becomes the organ fibrosis in recent years of research. This article to TGF-β1 and liver Fibrosis research reviewed in the paper. [Keywords:] transforming growth factor β1; liver fibrosis; extracellular matrix; hepatic stellate cells Liver fibrosis is the extracellular matrix (ECM) synthesis and degradation balance, causing excessive deposition of ECM in the liver caused. Has now been confirmed is the key to hepatic fibrosis hepatic stellate cells (HSC) activation and activation of ECM Abnormal expression. transforming growth factor TGF-β1 is activated HSC and to promote the expression of ECM key factor, is the primary regulatory factors of liver fibrosis. TGF-β1 signal transduction in HSC ECM expression regulation is the role of liver fibrosis the key to treatment [1]. 1 TGF-β1 structure, cell source and signal transduction 1.1 TGF-β1 Overview 1978 De Larco, etc. in the mouse sarcoma virus transformed cell lines have identified the medium to promote cell growth and transformation properties of the material, called transforming growth factor. Later found that TGF consists of two species composition: TGF-@, TGF-β [2]. TGF-β are dimeric peptide growth factor family, is a kind of activity with a variety of cytokines. is widely found in animal cells and transformation of normal cells . in the liver, TGF-β synthesis mainly produced by a number of non-parenchymal cells such as Kupffer cells, myofibroblasts and endothelial cells. in the TGF-β superfamily TGF-β subfamily, the current study reported that there were 6 TGF-β molecular species, namely TGF-β1 ~ 6.TGF-β1 ~ 6 expression in mammals and has been cloned is the TGF-β1 ~ 3. in the molecule TGF-β, TGF-β1 is the most studied and organ fibrosis, the development of closely r