Cyclin D1 and p16 expression in recurrent nasopharyngeal carcinoma.docVIP

World Journal of Surgical Oncology BioMedCentral Research Open Access Cyclin D1 and p16 expression in recurrent nasopharyngeal carcinoma Ho-Sheng Lin*1,2, Gerald J Berry3, Zijie Sun4 and Willard E Fee Jr5 Address: 1Department of Surgery, John D. Dingell VA Medical Center, 4646 John R. Street, Detroit, MI 48201, USA, 2Department of Otolaryngology, Wayne State University, 4201 St. Antoine, 5 E University Health Center, Detroit, MI 48201, USA, 3Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA, 4Department of Urology, Stanford University Medical Center, Stanford, CA 94305, USA and 5Department of Otolaryngology, Stanford University Medical Center, Stanford, CA 94305, USA Email: Ho-Sheng Lin* - hlin@; Gerald J Berry - GJBerry@; Zijie Sun - zsun@; Willard E Fee - wfee@ * Corresponding author Published: 05 September 2006 Received: 30 January 2006 Accepted: 05 September 2006 World Journal of Surgical Oncology 2006, 4:62 doi:10.1186/1477-7819-4-62 This article is available from: /content/4/1/62 ? 2006 Lin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Cyclin D1 and p16 are involved in the regulation of G1 checkpoint and may play an important role in the tumorigenesis of nasopharyngeal carcinoma (NPC). Previous studies have examined the level of expression of cyclin D1 and p16 in primary untreated NPC but no such information is available for recurrent NPC. We set out in this study to examine the expression level of cyclin D1 and p16 in recurrent NPC that have failed previous treatment with radiation +/- chemotherapy. Patients and methods: A total of 42 patients underwent salvage nasopharyngectomy from 1984 to 2001 for recurrent NPC after treatment