Th17细胞与自身免疫性甲状腺疾病研究进展.pdfVIP

Th17 细胞与自身免疫性甲状腺疾病研究进展 摘要：自身免疫性甲状腺疾病(AITD)是一组以甲状腺为靶器官的可影响全身 多个系统的自身免疫性疾病，其最常见类型为弥漫性毒性甲状腺肿(GD)和桥本 甲状腺炎(HT)。甲状腺相关眼病（TAO ）为与之相关的眼部表现。辅助型 T 细 胞 17 （Th17)是除了 Th1、Th2 两种经典辅助 T 细胞之外，发现的第三类新型 + CD4 辅助T 细胞亚群，主要表达白细胞介素17 （IL- 17）等效应因子，在免疫系 统中有其独特作用。近年来有关Th17 在自身免疫性疾病发病中的作用已成为研 究热点，来自不同研究机构的数据证实其在多种自身免疫性疾病中均发挥重要的 调节作用。随着研究的深入，人们发现Th17 细胞及其细胞因子亦参与了自身免 疫性甲状腺疾病(AITD)的发病过程。该文主要就 Th17 细胞及其细胞因子在 AITD 发病中的作用研究进展予以综述。 关键词：Th17 细胞；IL- 17；自身免疫性甲状腺疾病 1 The Progress on the Role of Th17 in Autoimmune Thyroid Diseases Pathogenesis Abstract Autoimmune thyroid diseases (AITD) is result from a deregulation of the immune system leading to an immune attack on the thyroid gland,which can affect multiple systems of our body.The most common AITD are Graves disease and Hashimoto thyroiditis.Thyroid-associated ophthalmopathy is also belongs to AITD. The identification of novel helper T(Th) cell subsets which is IL- 17-producing Th cells (Th17 cells) provided new insight for our understanding of the traditional help T cell system which only include Th1 and Th2 cells and the molecular mechanisms involved in the development of autoimmune diseases.In recent years,Th17 cells has attracted more and more attention.The data which come from different research institutions have proved the important role of Th17 cells in many kinds of auimmune diseases.Th17 cells may also contribute to the pat hogenesis of autoimmune thyroid disorders including Graves d isease,Hashimoto thyroiditis and Thyroid-associated ophthalmopathy.In this review,we summarize the current knowledge about the potential roles of IL- 17 and Th17 cells in the p