Association of Morphology and Immunophenotype in Diffuse Large B-Cell Lymphomas with Bone Marrow Infiltration in a Sample Mexican Population英文文献资料.docVIP

Open Journal of Pathology, 2012, 2, 29-37 29 Published Online April 2012 (http://www.SciRP.org/journal/ojpathology) /10.4236/ojpathology.2012.22007 Association of Morphology and Immunophenotype in Diffuse Large B-Cell Lymphomas with Bone Marrow Infiltration in a Sample Mexican Population* Mónica-Belinda Romero-Guadarrama , Fiacro Jiménez Ponce , Armando Medina Cruz , 1# 1 1 2 Elsa Lorena Durán Ramírez 1 , Icela Palma Lara 1 Unidad de Patología del Hospital General de México, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City, México; Molecular and Celular Morphology Laboratory, Escuela Superior de Medicina, Instituto Politécnico Nacional and Morphology Department, Facultad de Medicina Veterinaria y Zootecnia (UNAM), México City, México. 2 Email: monicaromero@.mx # Received January 26 , 2012; revised February 10 , 2012; accepted March 12 , 2012 th th th ABSTRACT Introduction: Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is a large B-cell lymphoma with a diffuse growth pattern and aggressive clinical course. It is divided in subgroups according to its morphology, immuno- phenotype, and primary site. Dissemination to bone marrow occurs in 11% to 35% of cases and can be of concordant or discordant morphology. Objective: To examine the association, the type of bone marrow involvement in relation to the primary site, morphology, immunohistochemistry of DLBCLs and to determine the cases of Epstein-Barr virus positive DLBCLs. Materials and Methods: We reviewed lymph node and extranodal biopsies as well as the respective bone marrow biopsies in all cases of DLBCL diagnosed in the Hospital General de México during the period from 2002 to 2