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Cell Proliferation Tracking Using Graphene Sensor Arrays英文文献资料.doc

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Cell Proliferation Tracking Using Graphene Sensor Arrays英文文献资料

HindawiPublishingCorporation JournalofSensors Volume2012,ArticleID219485,7pages doi:10.1155/2012/219485 ResearchArticle CellProliferationTrackingUsingGrapheneSensorArrays RonanDaly, 1 ShishirKumar, GyongyiLukacs, KanghoLee, AnneWeidlich, 1 2 1 1 andGeorgS.Duesberg 1 MartinHegner, 2 1 2 CRANNandSchoolofChemistry,TrinityCollegeDublin,Dublin2,Ireland CRANNandSchoolofPhysics,TrinityCollegeDublin,Dublin2,Ireland CorrespondenceshouldbeaddressedtoRonanDaly,dalyr1@tcd.ieand MartinHegner,martin.hegner@tcd.ie Received15June2011;Revised25August2011;Accepted25August2011 AcademicEditor:MariaTenje Copyright?2012RonanDalyetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. The development of a novel label-free graphene sensor array is presented. Detection is based on modi?cation of graphene FETdevicesandspeci?callymonitoringthechangeincompositionofthenutritivecomponentsinculturingmedium.Micro- dispensing of Escherichia coli in medium shows feasibility of accurate positioning over each sensor while still allowing cell proliferation.GrapheneFETdevicefabrication,sampledosing,andinitialelectricalcharacterisationhavebeencompletedand showapromisingapproachtoreducingthesamplesizeandleadtimefordiagnosticanddrugdevelopmentprotocolsthrougha label-freeandreusablesensorarrayfabricatedwithstandardandscalablemicrofabricationtechnologies. 1.Introduction changeinthecomponentsofthebulknutritiveliquid.We proposetheuseofascalablegrapheneFETmicrofabrication technologyto(i)growgraphene?lmsbychemicalvapour deposition, (ii) transfer them to functional substrates and (iii) microstructure and contact graphene devices. These grapheneFETsarefunctionalisedbydirectmicrodispensing of biological materials. We show initial evidence for cell proliferationonthemicrofabricateddevicesandthechange ingraphenechargetransportresponseswi