Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries a randomised, controlled trial [ISRCTN50308308] 英文参考文献.docVIP

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Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries a randomised, controlled trial [ISRCTN50308308] 英文参考文献.doc

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Available online /content/8/4/R268 Research Open Access October 2004 Vol 8 No 4 Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCT Andreas Karabinis1, Kostas Mandragos2, Spiros Stergiopoulos3, Apostolos Komnos4, Jens Soukup5, Ben Speelberg6 and Andrew JT Kirkham7 1Director of Intensive Care Unit, Genimatas General Hospital, Athens, Greece 2Director of Intensive Care Unit, Red Cross General Hospital of Athens, Korgialenio, Benakio, Athens, Greece 3Assistant Professor of Surgery, Head of SICU and Trauma Unit, 4th Surgical Department, Athens Health Science University, Athens, Greece 4Director of Department of Intensive Care, General Hospital of Larissa, Larissa, Greece 5Anesthesiologist, Department of Anesthesiology and Intensive Care Medicine, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany 6Internist-Intensivist, Intensive Care, St Elisabeth Ziekenhuis, Tilburg, The Netherlands 7Anaesthesia Clinical Development, GlaxoSmithKline, Greenford, Middlesex, UK Corresponding author: Andreas Karabinis, akarab@ath.forthnet.gr Received: 8 April 2004 Critical Care 2004, 8:R268-R280 (DOI 10.1186/cc2896) This article is online at: /content/8/4/R268 Revisions requested: 17 May 2004 Revisions received: 26 May 2004 Accepted: 28 May 2004 Published: 28 June 2004 Abstract Introduction This randomised, open-label, observational, multicentre, parallel group study assessed the safety and efficacy of analgesia-based sedation using remifentanil in the neuro-intensive care unit. Methods Patients aged 18–80 years admitted to the intensive care unit within the previous 24 hours, with acute brain injury or after neurosurgery, intubated, expected to require mechanical ventilation for 1–5 days and requiring daily downward titration of sedation for assessment of neurological function were stud