Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor 英文参考文献.docVIP
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Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor 英文参考文献
Behavioral and Brain Functions
BioMedCentral
Short paper
Open Access
Two inbred rat strains contrasting for anxiety-related behaviors
show similar levels of defensive responses to cat odor
Gustavo R Brüske, Leandro F Vendruscolo* and André Ramos
Address: Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa
Catarina, Florianópolis, SC, Brazil
Email: Gustavo R Brüske - gustavobruske@; Leandro F Vendruscolo* - vendruscolo@;
André Ramos - andre@ccb.ufsc.br
* Corresponding author
Published: 13 April 2007
Received: 19 October 2006
Accepted: 13 April 2007
Behavioral and Brain Functions 2007, 3:17
doi:10.1186/1744-9081-3-17
This article is available from: /content/3/1/17
? 2007 Brüske et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Rodents are known to display fear-related responses when exposed to the odor of natural
predators, such as cats, even when they are totally na?ve to these stimuli. Based on that, a
behavioral test in which rats are exposed to cat odor has been developed and proposed to model
some forms of anxiety. The objective of the present study was thus to compare the LEW (Lewis)
and SHR (spontaneously hypertensive rats) inbred rat strains, which display genetic differences in
other classical models of anxiety, in the cat odor test. As expected, cat odor produced an increase
in fear-related behaviors. However, no clear differences were found between the two strains
tested. These results suggest that the type of stress experienced by LEW and SHR strains exposed
to cat odor is different from that elicited by exposure to classical models of anxiety such as the
elevated plus-maz
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