超剂量黄连素联合甲氧苄啶治疗老年慢性痢疾.pdfVIP

· 6O· 医药论坛杂志 2007年12月 第28卷 第24期 厶 超剂量黄连素联合甲氧苄啶I1：=1 7 J 老年慢性痢疾 杨 燕，李亚利，张丽华，陈秋征 商丘市第一人民医院感染科 商丘市 476100 摘要 目的 探讨治疗老年慢性细菌性痢疾的简便有效方法。方法 将患者随机分为两组，甲组给予黄 连素0．6g口服，每日3次，甲氧苄啶(TMP)0．3g口服，每日一次，连用7天，乙组用头孢曲松2g加入生理盐水 250ml中静脉点滴，每日1次，左氧氟沙星0．2g加入5％葡萄糖溶液250ml中静脉点滴，每日2次，连用7—10 天。结果 甲组33例，治愈31例，治愈率93．94％，乙组31例，治愈26例，治愈率83．87％。统计学处理(x。= 1．66，P0．10)疗效无显著差异。结论 超剂量黄连素联合甲氧苄啶治疗老年慢性菌痢为一简便有效方法。 关键词 黄连素；TMP；细菌性痢疾；慢性：老年人 中图分类号：R516．4 文献标识码：B 文章编号：1672．3422(2007)24-0060-02 Curing Elderly Person s Chronic Bacterial Dysentery Ⅵrith Transnormal Dosages of Berberine Associated with TMP YANG Yah，LI Yali，ZHANG Lihua，et al Department ofInfection，The First Peoples Hospital ofShangqiu，City Shangqiu 476100，China ABSTRACT Objective To explore the simple and convenient effective method to cure elderly person chronic bacterial dysentery．Methods The patients were divided into two groups at random． Group A takes the berberine 0．6g three times a day and TMP 0．3g once a day orally and it continues for seven days．The group B is treated by intravenous drip with ceflriaxone 2g associated with 250ml of physiological saline once a day and levofloxacin 0．2g associated with 5％ of glucose solution 250ml twice a day and it continues for seven or ten days．Results Total 31 cases of group A(33 cases)were cured and the curative rate is 93．94％，26 cases of group B(31 cases)were cured and the curative rate is 83．87％．According to the statistical processing X2=1．66，so the curative effect has no distinctive difference(P0．0 1)．Conclusion Overdose berberine associated with TMP is a simple