醒脑静注射治疗鞍区肿瘤术后下丘脑功能紊乱的临床研究.pdfVIP

Journal of Medical Forum Vo1．28 No．24 December 2007 · 5· 醒脑静注射治疗鞍区肿瘤术后 下丘脑功能紊乱的临床研究 王新军，高 涛，寿纪新，李培栋，刘 泉，吴建珩 郑州大学第五附属医院神经外科 郑州市 450052 摘要 目的 评价醒脑静注射液在鞍区肿瘤术后下丘脑功能紊乱治疗中的I临床疗效。方法 ll2例累及 丘脑下部的鞍区肿瘤患者术后治疗随机分成两组，对照组46例，常规进行术前准备及术后处理，出现并发症后 积极常规治疗。研究组66例，在对照组常规治疗的基础上加用醒脑静注射液10～20ml，l一2次／d。比较分析 两组病例术后生命体征、中枢性高热、癫痫发作、消化道应激性溃疡以及颅内压和脑水肿等并发症的差异。结果 研究组：中枢性高热、颅内压、脑水肿、尿崩症、癫痫、消化道出血、血电解质紊乱等的发生率均较对照组低(P 0．05或P0．01)。结论 巨大鞍区肿瘤术后早期应用醒脑静可以有效地控制和降低中枢性高热，减轻脑水 肿，降低颅内压升高幅度，阻止下丘脑功能继发性损害，减轻术后并发症的程度，是提高鞍区肿瘤临床治疗效果 的重要措施。 关键词 醒脑静；鞍区肿瘤；下丘脑功能紊乱 中图分类号：R730．6 文献标识码：A 文章编号：1672-3422(2007)24-0005-03 Clinical Therapeutic Observation of Xingnaojing Injection in Sellar Region Tumor Postoperative Hypothalamic Function Disorder WANG Xinjun，GAO Tao，SHOU Jixin，et al Department ofNeurosurgery，the Fifth．Affiliated Hospital ofZhengzhou University，Zhengzhou 450052，China ABSTRACT Objective To evaluate the clinical curative effect of Xingnaojing Injection on sellar region tumour postoperaive hypothalamic function disorders．Methods All 1 1 2 patients with tumor at sellar region postoperative treatment were randomly divided into two groups：Control group 46 cases，preoperative preparation and postoperative treatment were done ordinarily，the postoperative corn— plications were treated actively．Studing group 66 cases，postoperative treatment of the hypothalamic function disorders was added Xingnaojing Injection on the basis of the control group treatment．Contrast observe the difference of complication between the two groups．Results Incidence of Centrum Hyper thermia，recoving consciousness，diabetes insipidus，blood electrolyte disorder，alimentary hemorrhage，