奇正消痛贴膏对兔耳软组织损伤影响的活体观察.pdfVIP

· 356· 中国骨伤2008年5月第21卷第5期 China J Orthop＆Trauma，May．2008，Vo1．21，No．5 · 基 础 研 究 · 奇正消痛贴膏对兔耳软组织损伤影响的活体观察 王永志，董福慧，钟红刚，张万强 (中国中医科学院骨伤科研究所，北京 1~700) 【摘要】 目的：观察奇正消痛贴膏对活体兔耳软组织微循环的影响，为临床应用提供基础资料。方法：新西兰大 白兔 10只，制作兔耳软组织损伤模型，在第1、2、3周分为3组，每组10只兔耳，空白给药组和实验组兔耳外敷奇正消 痛贴膏提取液，模型组外用生理盐水。采用显微放大、数字采集系统，红外测温仪及测厚仪等对用药后0、0．5、3、5 h的 兔耳软组织局部微循环血流速度、温度的变化进行观察，同时观察第1～5天的兔耳局部肿胀程度。结果：空白给药组 3 h的血流速度加快，5 h恢复正常。模型组3、5 h的速度持续加快。与模型组比较，实验组5 h血流速度明显慢，兔耳损 伤部位肿胀程度于3、4、5 h明显缩小。结论：奇正消痛贴的应用能明显减轻损伤急性期微循环血流速度的加快。防止 进一步水肿及出血。在慢性期，能够有效地减小兔耳损伤部位肿胀程度，与急性期比较，明显发挥消肿作用。 【关键词】 奇正消痛贴； 软组织损伤； 外治法；微循环； 动物实验 In vivo effects of Qizheng-xiaotong plaster on soft tissue injury of rabbit ears WANG Yong—zhi，DONG Fu—hui， ZHONG Hong-gang，ZHANG Wan-qiang．Institute ofOrthopedic and Traumatology，ChinaAcademyofChinese Medical Sci— ences，Be~iing 100700，China ABSTRACT Objective：To explore in vivo effects of Qizheng-xiaotong plaster on soft tissue injury in rabbit ears at different periods and to offer theoretical bases for clinical application．Methods：The experimental models of soft tissue injury in ears were produced in 10 New Zealand white rabbits，and the ears were divided into tllree groups at tlle 1st，2nd，3rd week．The nor- mal group and treatment group were given the Qizheng-xiaotong plaster extract．and the model group witll normal saline．Micro— scopic analysis。digital collection system。infrared temperature tester and thickness tester were applied to determ ine the changes of soft tissue injury in local microcirculation and the temperature change after 0，0．5，3 and 5 hours，and swelling change at 1 to 5 days respectively． ts：At the 3rd hour，blood velocity speeded up in normal group and model group，and it lasted for two hours in model group．As compared with model group，it slowed down to original level in treatment group at the 5th hour and the soft tissue swelling decreased from