elevated circulating interleukin-27 in patients with coronary artery disease is associated with dendritic cells, oxidized low-density lipoprotein, and severity of coronary artery stenosis升高循环interleukin-27冠状动脉疾病患者与树突细胞有关,氧化低密度脂蛋白,冠状动脉狭窄的严重程度.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 506283, 10 pages doi:10.1155/2012/506283 Research Article Elevated Circulating Interleukin-27 in Patients with Coronary Artery Disease Is Associated with Dendritic Cells, Oxidized Low-Density Lipoprotein, and Severity of Coronary Artery Stenosis Wen Jin,1 Yiqiao Zhao,1 Wen Yan,2 Longxing Cao,3 Weiwei Zhang,3 Ming Wang,4 Ting Zhang,1 Qiang Fu,3 and Zhiliang Li3 1 Cardiovascular Department, Guangdong No.2 Provincial People’s Hospital, Guangdong 510317, China 2 Oncology Department, Guangdong No.2 Provincial People’s Hospital, Guangdong 510317, China 3 Cardiovascular Department, Zhujiang Hospital, Southern Medical University, Guangdong Province, Guangdong 510282, China 4 Traditional Chinese Medicine Department, Zhujiang Hospital, Southern Medical University, Guangdong 510282, China Correspondence should be addressed to Qiang Fu, fuqiang020@126.com and Zhiliang Li, lizhiliang020@126.com Received 12 March 2012; Revised 26 April 2012; Accepted 15 May 2012 Academic Editor: Hidde Bult Copyright © 2012 Wen Jin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Coronary artery disease (CAD) is an immune-mediated chronic inflammatory disease mainly caused by atherosclerosis. The aims of this study were to investigate the role of interleukin-27 (IL-27) in patients with CAD and the severity of coronary artery lesions, which was evaluated by Gensini score and to investigate the biosynthesis of IL-27 and oxidized low-density lipoprotein (ox-LDL) in vitro using monocyte-derived dendritic cells (DCs). To this aim, plasma levels of IL-27, ox-LDL, and Gen