bone and energy metabolism parameters in professional cyclists during the giro d’italia 3-weeks stage race骨头和能量代谢参数在专业自行车在一种直升机环意大利自行车赛u201d3周阶段比赛.pdfVIP

Bone and Energy Metabolism Parameters in Professional Cyclists during the Giro d’Italia 3-Weeks Stage Race 1 1 2 1 1,3 Giovanni Lombardi *, Patrizia Lanteri , Rosa Graziani , Alessandra Colombini , Giuseppe Banfi , Roberto Corsetti4 1 I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italia, 2 CEDAL Lab, Gallarate, Italia, 3 Chair of Clinical Biochemistry, School of Medicine, University of Milano, Milano, Italia, 4 Liquigas Cannondale pro-cycling team, Medical board, Sesto al Reghena, Italia Abstract Cycling is a not weight-bearing activity and is known to induce bone resorption. Stage races are really strenuous endurance performances affecting the energy homeostasis. The recently highlighted link, in the co-regulation of bone and energy metabolism, demonstrates a central role for the equilibrium between carboxylated and undercarboxylated forms of osteocalcin. Aim of this study was to understand the acute physiological responses to a cycling stage race in terms of bone turnover and energy metabolism and the possible co-regulative mechanisms underlying their relationship. We studied nine professional cyclists engaged in 2011 Giro d’Italia stage race. Pre-analytical and analytical phases tightly followed academic and anti-doping authority’s recommendations. Bone and energy metabolism markers (bone alkaline phosphatase, tartrate- resistant acid phosphatase 5b, total and undercarboxylated osteocalcin, leptin and adiponectin) and related hormones (cortisol and testosterone) were measured, by Sandwich Enzyme Immunoassays, at days -1 (pre-race), 12 and 22 during the race. The power output and the energy expenditure (mean and a