copy number variation in subjects with major depressive disorder who attempted suicide拷贝数变异与重度抑郁症受试者试图自杀的人.pdfVIP

Copy Number Variation in Subjects with Major Depressive Disorder Who Attempted Suicide 2 2 3 1,2 Roy H. Perlis , Douglas Ruderfer , Steven P. Hamilton , Carl Ernst * 1 Department of Psychiatry, McGill University, Montreal, Quebec, Canada, 2 Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America Abstract Background: Suicide is one of the top ten leading causes of death in North America and represents a major public health burden, partcularly for people with Major Depressive disorder (MD). Many studies have suggested that suicidal behavior runs in families, however, identification of genomic loci that drive this efffect remain to be identified. Methodology/Principal Findings: Using subjects collected as part of STAR*D, we genotyped 189 subjects with MD with history of a suicide attempt and 1073 subjects with Major Depressive disorder that had never attempted suicide. Copy Number Variants (CNVs) were called in Birdsuite and analyzed in PLINK. We found a set of CNVs present in the suicide attempter group that were not present in in the non-attempter group including in SNTG2 and MACROD2 – two brain expressed genes previously linked to psychopathology; however, these results failed to reach genome-wide signifigance. Conclusions: These data suggest potential CNVs to be investigated further in relation to suicide attempts in MD using large sample sizes. Citation: Perlis RH, Ruderfer D, Hamilton SP, Ernst C (2012) Copy Number Variation in Subjects with Major Depressive Disorder Who Attempted Suicide. PLo