high-dose levofloxacin in the treatment of lower respiratory tract infection in elderly analysis of 32 cases（高剂量左氧氟沙星治疗老年下呼吸道感染分析32例）.docVIP

High-dose levofloxacin in the treatment of lower respiratory tract infection in elderly Analysis of 32 Cases [Abstract] Objective To evaluate the high-dose levofloxacin treatment of elderly patients with lower respiratory tract infection in the clinical efficacy and safety. Methods 32 elderly patients with lower respiratory tract bacterial infection, the use of levofloxacin (L g) 500mg / d an intravenous infusion therapy, treatment 7 14 days results in patients with cough, expectoration, fever, lung wet rales, and peripheral blood recovery of more than 80.00% effective rate in the clinical total effective rate was 90.63%, 76.72% rate of bacterial clearance, adverse drug reactions rates were 12.50%, and reported similar findings of high-dose levofloxacin in the treatment of lower respiratory tract infection in elderly good efficacy, the treatment of lower respiratory tract infection in elderly compared with the ideal antibiotics. [Key Words] high-dose levofloxacin in elderly patients with lower respiratory tract infection Levofloxacin is widely used in the treatment of various system consists of bacterial infections caused by susceptible strains, previous conventional usage, dosage of 200mg, twice daily dosing, but in recent years with the quinolone antibacterial drug pharmacokinetics (PK and pharmacodynamics (PD Research continues to deepen, the results show high-dose levofloxacin (500mg or 750mg), once a day dosing regimen is more reasonable than the low dose in divided doses better, resulting in less chance of bacterial resistance less, and no increase in adverse reactions. I Division the past two years the use of high doses of levofloxacin (L g) in the treatment of lower respiratory tract infection in elderly and achieved satisfactory results, are reported below. Object and methods 1 1.1 Case Selection April 2009 - March 2011 32 patients hospitalized in our department, age 65, of which 65-70 years in 12 cases ,71-80 years old in 16 cases, 81