原创力文档preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamicscurcumin-loaded脂质体的制备和评价他们的皮肤渗透和药效学.pdfVIP
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preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamicscurcumin-loaded脂质体的制备和评价他们的皮肤渗透和药效学
Molecules 2012, 17, 5972-5987; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Preparation of Curcumin-Loaded Liposomes and Evaluation of
Their Skin Permeation and Pharmacodynamics
Yan Chen *, Qingqing Wu, Zhenghai Zhang, Ling Yuan, Xuan Liu and Lei Zhou
Key Laboratory of New Drug Delivery Systems of Chinese Meteria Medical, Jiangsu Provincial
Academy of Chinese Medicine, Nanjing 210028, China; E-Mails: wqq18314@126.com (Q.W.);
davidpharm@ (Z.Z.); yuanl.china@ (L.Y.); liu_xuan1987@163.com (X.L.);
youleiwuheng@ (L.Z.)
* Author to whom correspondence should be addressed; E-Mail:ychen202@;
Tel.: +86-25-8560-8672; Fax: +86-25-8563-7809.
Received: 9 April 2012; in revised form: 8 May 2012 / Accepted: 9 May 2012 /
Published: 18 May 2012
Abstract: This study aimed to investigate the in vitro skin permeation and in vivo
antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery
system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated
soybean phospholipids (HSPC) were selected for the preparation of different kinds of
phospholipids composed of curcumin-loaded liposomes: C-SPC-L (curcumin-loaded SPC
liposomes), C-EPC-L (curcumin-loaded EPC liposomes), and C-HSPC-L (curcumin-loaded
HSPC liposomes). The physical properties of different lipsomes were investigated as
follows: photon correlation spectroscopy revealed that the average particle sizes of
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