抗人呼吸道合胞病毒中药抑制剂研究进展.PDFVIP

·3650 · 中草药 Chinese Traditional and Herbal Drugs 第48 卷 第17 期 2017 年9 月 抗人呼吸道合胞病毒中药抑制剂研究进展 张梦迪，王厚伟* 山东中医药大学药学院 山东济南长清大学科技园，山东 济南 250355 摘 要：人呼吸道合胞病毒 （hRSV ）是世界范围内婴幼儿下呼吸道感染的重要病原病毒之一，至今缺乏有效的hRSV 感染 治疗药物和疫苗。从中药有效成分、单味中药、中药复方抑制剂研发3 个方面，对抗hRSV 感染中药的最新研究进展进行综 述，为抗hRSV 新药研发与探索新的hRSV 感染的治疗策略奠定理论基础。 关键词：人呼吸道合胞病毒；呼吸道感染；中药；中药复方；新药研发 中图分类号：R282.71 文献标志码：A 文章编号：0253 - 2670(2017) 17 - 3650 - 04 DOI: 10.7501/j.issn.0253-2670.2017. 17.031 Research progress on Chinese materia medica inhibitors with anti-human respiratory syncytial virus effect ZHANG Meng-di, WANG Hou-wei College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji’nan 250355, China Abstract: Human respiratory syncytial virus (hRSV) was considered to be the leading cause of lower respiratory tract disease in infants and young children. So far, there was a lack of effective anti-hRSV drugs and vaccines. In this paper, the latest research progress on anti hRSV infection drugs was reviewed from three aspects of effective constituents of Chinese materia medica, Chinese materia medica, and Chinese medicine compound antiviral inhibitor research and development, which would lay a theoretical foundation for the research and development of anti-hRSV drugs and the anti hRSV infection treatment strategy. Key words: human respiratory syncytial virus; respiratory tract infections; Chinese materia medica; Chinese materia medica compound; new drug development 人呼吸道合胞病毒 （human respiratory syncytial 广泛使用。因此，hRSV 感染性呼吸道疾病仍然以 [6] virus ，hRSV ）是一种引发婴幼儿、儿童、老年人等 药物治疗为主 。中药治疗传染性疾病已有 2 000 [1] 免疫力低下者各种呼吸道疾病的常见RNA 病毒 。 年之久，在古代文献中记载了超过 1 万种草药和10 全球每年约有16 万例婴幼儿死于hRSV 引发的下呼 万份食谱，为筛选有效的药物提供了丰富的资源。