孟鲁司特在毛细支气管炎恢复期患儿的临床应用探讨.docVIP

精品论文 参考文献 孟鲁司特在毛细支气管炎恢复期患儿的临床应用探讨 杜雪梅 张娟 涂亚娟 王芬 吴家富 [摘 要]目的:了解孟鲁司特对毛细支气管炎恢复期气道高反应性（airway hyperresponsiveness,AHR）的干预效果，探讨其在该群体患儿的临床应用意义。方法:收集2012年2月至2015年1月本院和外院首次确诊为毛细支气管炎治愈出院后，因出院半年内喘息反复发作3次以上,发病年龄大于1岁的患儿共189例，以其中人工支气管激发实验（bronchial provocation test,BPT）阳性的116例为研究对象。随机分为观察组和对照组，观察组56人，对照组60人，两组年龄、性别无显著差异，两组皆给予支气管扩张剂及对症治疗至喘息停止。之后观察组给予每晚口服孟鲁司特一次：6月－2岁2.5 mg/次，2岁以上4 mg/次共3个月；对照组不用该药。观察两组患儿在半年内喘息再发情况。结果：经过孟鲁司特治疗后半年内观察组再次发作喘息者较对照组明显减少。结论：孟鲁司特可降低毛细支气管炎后的气道高反应性，可预防婴幼儿短期内喘息反复发作和哮喘的发生。 [关键词]孟鲁司特钠 毛细支气管炎 恢复期 气道高反应性 喘息 DOI:10.3760/cma.j.issn.0376-2491.2016.28.51 作者单位：621700，四川省江油，四川省江油903医院 Clinical application of montelukast in bronchiolitis recovery stage Du Xuemei, Zhang Juan, Tu Yajuan, Wang Fen, Wu Jiafu Abstract： Objective: To investigate the montelukast recovery airway hyperresponsiveness to bronchiolitis (airway hyperresponsiveness, AHR) the effect of intervention, and to explore its significance in clinical application of this group of children. Methods: from 2011 February to 2013 January in our hospital and the outer court first diagnosed with bronchiolitis were cured after discharge, because within six months of breathing again second episodes to the pediatric clinic, onset age more than in June of 189 cases, in which the artificial bronchial provocation experiment (bronchial provocation test, BPT) of 116 patients positive for study object. Were randomly divided into the observation group and the control group, the observation group of 56 people, 60 in the control group, no significant difference between the two groups in age, gender, two groups received bronchodilators and symptomatic treatment to stop breathing. Every night after the observation group was given oral montelukast once: in June 2 at the age of 2.5 mg/ times, 2 above the age of 4 mg/ total of 3 months; the control group without the drug. The two groups were observed in the six months to the recurrent situation. Results: after six months of montelukast treatment observation group again a