门冬氨酸鸟氨酸减少肝动脉化疗栓塞术后轻微型肝性脑病发生的临床研究.docVIP

精品论文 参考文献 门冬氨酸鸟氨酸减少肝动脉化疗栓塞术后轻微型肝性脑病发生的临床研究 亢春生 刘建新 李彪 张菲菲 贾丽彬 　　（潞安集团总医院 山西长治 046204） 　　【摘要】目的 研究门冬氨酸鸟氨酸减少原发性肝癌肝硬化患者行肝动脉化疗栓塞术后轻微型肝性脑病发生的临床作用。方法 100例原发性肝癌肝硬化患者随机分为治疗组和对照组，各50例。治疗组患者在基础保肝治疗上加用门冬氨酸鸟氨酸。对照组给予基础保肝治疗。肝动脉化疗栓塞术后7天行心理智能测试检测。术前1天及术后7天查血氨及相关生化指标。结果 治疗组肝动脉化疗栓塞术后轻微型肝性脑病检出6例（12%），对照组28例（56%），chi;2=21.57，Plt;0.001，差异有统计学意义。结论 门冬氨酸鸟氨酸能有效降低肝动脉化疗栓塞术后患者的血氨水平，保护肝功能，降低轻微型肝性脑病发病率。 　　【关键词】??冬氨酸鸟氨酸 减少 肝动脉化疗栓塞术 轻微型肝性脑病 　　【中图分类号】R969 【文献标识码】A 【文章编号】2095-1752（2014）11-0076-02 　　Clinical study on L-ornithine-L-aspartate reducing the incidence rate of Minimal hepatic encephalopathy after Transcatheter arterial chemoe-mblization. 　　KANG chun-sheng , LIU jian-xin,LI biao, ZHANG fei-fei ,JIA li-bin 　　Hospital of Lu an group, Changzhi 046204 　　【Abstract】Objective To study the clinical effect of L-ornithine-L-aspartate reducing the incidence rate of Minimal hepatic encephalopathy (MHE) after Transcatheter arterial chemoe-mblization（TACE）operated hepatocellular carcinoma with cirrhosis patients. Methods 100 cases of patients with hepatocellular carcinoma accompanying cirrhosis were randomly divided into treatment group and control group, 50 cases in each. Patients in the treatment group were added with ornithine aspartate in foundation treatment. The control group was given basic treatment of liver. 7 days after TACE,intelligent mental test. 1 days before operation and 7 days after operation, blood ammonia and biochemical parameters. Results 6 cases of Minimal hepatic encephalopathy were detected in treatment group TACE after operation (12%), 28 cases in the control group (56%),chi;2=21.57 , P lt;0.001,the difference was statistically significant. Conclusion L-ornithine-L-aspartate can effectively reduce the level of blood ammonia in patients after TACE, protect the liver function, reduce the incidence rate of Minimal hepatic encephalopathy . 　　【Key words】L-ornithine-L-aspartate reduce TACE Minimal hepatic