药理学讲义01 Introduction.pptVIP

* * Pharmacology药理学Introduction What is pharmacology? Drug 药物 Pharmacology is the study of interactions between drugs and the body Body 身体 What is pharmacology? Drug 药物 Pharmacology is the study of interactions between drugs and the body Body 身体 Pharmacodynamics 药物效应动力学 is the study of what the drug does to the body What is pharmacology? Drug 药物 Pharmacology is the study of interactions between drugs and the body Body 身体 Pharmacodynamics 药物效应动力学 is the study of what the drug does to the body Absorption, distribution, elimination are what the body does to the drug Pharmacokinetics 药物代谢动力学 studies the concentrations (浓度) over time Action on the body Drug 药物 Action on the body Drug 药物 Poison 毒物 Action on the body Drug 药物 Dose 剂量 Poison 毒物 Indication 适应征 Adverse reaction Contra-indication Clinical pharmacology Toxicology 临床药理学 毒物学 Highlights of theHistory of Pharmacology The Egyptian ??Ebers?? papyrus from the 16th century BC is the oldest complete medical document still in existence. It is mainly a collection of prescriptions (处方) for various symptoms (症状). 神农本草经 (Shennong’s Classic of Herbal Medicine) is considered to be the earliest Chinese pharmacological work, a compilation of all medicinal knowledge accumulated around the first century BC. Tang Dynasty’s 新修本草 (Revised Canon of Materia Medica) is the first official pharmacopoeia (药典) in the world, dating from 659. Ming Dynasty’s 李时珍 writes the 本草纲目 (Compendium of Materia Medica) in 1596. It is the classical reference of Traditional Chinese Medicine, or TCM. It consists of 52 volumes detailing more than 1800 drugs. It is a must-have for TCM scholars today. German chemist F. W. Sertürner (1783-1841) is the first to isolate morphine (分离提纯吗啡) from the poppy. Experimentation on dogs proves its analgesic action. ISOLATION (分离) OF COMPOUNDS German microbiologist P. Ehrlich tests hundreds of chemical substances on syphilis. The 606th substance tested, an arsen