脑力劳动者职业紧张与5-HT2A受体基因rs6313位点多态性对睡眠质量影响的研究.DOCVIP

The effect of occupational stress and rs6313 Polymorphism of 5-hydroxytryptamine 2A receptor gene on sleep quality in brain worker FU Ailing GE Hua ZHANG Guanghui ZHU Zihao GU Kunpeng WU Wenfeng LIU Jiwen LIAN Yulong School of Public Health, Xinjiang Medical University; School of Public Health， Nantong University; Abstract： Objective To explore the effect of occupational stress and rs6313 polymorphism of 5-HT2 Arcccptor gene on sleep quality in brain workers. Methods (1) A stratified cluster random sampling method was used to collect 2 400 employees aged between 18 and 60 years. The occupational stress inventory revised edition (OST-R) and the Pittsburgh sleep quality index (PSQI) were used to investigate the occupational stress and the quality of sleep respectively- (2) 825 workers were extracted ancl their genotypes of rs6313 were determined by using SNaPshot method. Results Compared with the, the scores of ORQ and PSQ in brain worker were higher than those in the domestic norm, and the PRQ score was lower than the domestic norm (P 0. 05) ;The significant difference between sleep quality and occupational stress was statistically (P 0. 05) ;There was no statistically significant difference in the genotypes of rs6313 between good and poor sleep quality groups (P 0.05) . Conclusion There might be a relationship between occupational stress and sleep quality in brain workers.The rs6313 polymorphism of 5-HT2 Areceptor gene may be independent of sleep quality. Keyword： occupational stress; 5-HT2八 receptor gene; sleep quality; Received： 2017-04-18 睡眠质量是影响人体健康的重要因素之一。越来越多的研宄结果显示，睡眠障碍 的发生率在不断升高，睡眠障碍正成为困扰职业人群身心健康的一大问题。睡眠 障碍的发生不但与环境（轮班作业制度、紧张）有关，也与基因等遗传因素有 关。许多心身疾病和工伤的发生均与劳动荠长期超负荷的紧张状态密切相关，慢 性的高度紧张还会增加劳动者睡眠障碍发生的风险Elmenhorst等U1的 研究显示，5-HT2A受体表达的减少有助于睡眠质量的改善。Weisstaub等［4］提 出缺少5-HT2A受体的小鼠的唤醒、觉醒及睡眠节律会受到一定程度的影响。 5-11T2A受体基因由2个内含子和3个外显子组成，约20kbp大小，处在3ql4?21 区域。目前，国内外不乏关于5-HT2A受体基因与睡眠障碍之间关系的研宂，但 其结论尚未统一，关于rs6313位点多态性的研宄较少。本研宄的重点在于探讨 脑力劳动人群职业紧张与rs6313位点多态性对睡眠质量的影响。 1对象与方法 1.1研宄对象 本研宂