微流控中液滴的形成与操纵机理及其实验分析-mechanism and experimental analysis of droplet formation and manipulation in microfluidic.docxVIP

AbstractFluidisanimportantexistenceformofobjects,whilemicrofluidicsfoucusonthemanipulationoffluidsinmicroscale.Dropletisanewbranchofthemicrofludicsinrecentyears,whichisregardedasanindependentmicro-reactor.Theresearchonthereactioninthedropletiscrucialforthenewmicrofluidicwork.Comparedwithtranditionalchemicalreaction,droplethasmanyadvantages,suchaslowsampleconsumption,rapidresponse,andnopollutionetc,resultinginitsextendapplicationonchemicalsythesis,nanomaterialpreparation,cellanalysisanddrugsorting.However,theformationandmanipulationofdropletsarethefoundationofaboveresearch,butthepreviousworkisnotdeep.Dependingonthiscondition,thethesiswillfocusonthebasicmechanismofthedropletformationandmanipulation,inordertoachievetheprecisecontrolofdrolets,whichissignificantforthemicrofluidics.Firstly,researchactualityisreviewed,andthebasicmechanismforthetwophaseflowisproposed,includingthenon-dimensionalparametersindropletdynamics,wallwettingproperties,contactangleandmarangonieffectetc.ThedropletformationmechanismsforTshapemicrochannel,streamfocusing,andcoaxialfluidsaredescribed,meanwhilethebasicmanipulationmechanismsareanalyzed.Secondly,themodelsforkindsofmirochannelaresetupandsimulatedbysettingthesuitableboundaryconditions,andusingthelevelsetmethods.Moreover,themanipulatemodelsfortransport,splitandfusionarefounded,andalsoobtainthesimulationresults,providingparameterscomparationfortheexperiments.Finally,themicrochipsforthedropletformationandmanipulationarefabricatedusingstanderdlitography.ThemethodsincludingtheTshapemicrochannel,streamfocusing,andcoaxialfluidsareemployedtocreatesteadyandhomogeneousdroplets.Inaddition,theyeastcellsarepackedbythedroplets,achievingthedropletstransport,split,fusionandmixingetc.Thechipswiththeintegratedfunctionsarecarriedout,inordertoachievetheparallelfuctions,whichverifythetheoreticalandsimulationresultseffectively.Keywords:DropletFormation;DropletManipulation;Microfluidic;ChannelStructure目录摘要.............................................................