BNP与NT―proBNP诊断心力衰竭临床意义.docVIP

BNP与NT―proBNP诊断心力衰竭临床意义 　　【摘要】 目的：探讨B型脑利钠肽（BNP）与氨基末端B型脑利钠肽原（NT-proBNP）在心力衰竭（以下简称心衰）患者血中的水平变化及临床意义。方法：回顾分析2013年7月1日-2014年6月30日本院心血管内科收治的82例心力衰竭患者（心衰组），采用纽约心脏病学会（NYHA）标准对心功能分级和超声心动图检查评定患者心功能，以同期住院心功能正常的患者60例作为对照组。所有患者均空腹抽取静脉血，分析2个指标（BNP、NT-proBNP）与左室射血分数（LVEF）及NYHA不同心功能级别患者之间水平的差异。结果：心衰组血BNP及NT-proBNP水平显著高于对照组，差异有统计学意义（P0.01）。在心衰组中，随着NYHA分级增加，BNP、NT-proBNP水平逐渐升高，不同心功能级别间2个指标水平差异均有统计学意义（P0.01）；2个指标水平与心功能分级呈明显正相关性，与LVEF分级呈负相关。结论：BNP、NT-proBNP是心衰诊断的标志物，对不同程度心衰的鉴别诊断、危险分层、指导临床治疗具有重要临床意义。 　　【关键词】 心力衰竭； B型脑利钠肽； 氨基末端B脑利钠肽原 　　The Clinical Significance of BNP and the NT-proBNP in the Diagnosis of Heart Failure/ZHUO Yi-chun，CHEN Xue-li，HUANG Lie-kun.//Medical Innovation of China，2015，12（15）：047-049 　　【Abstract】 Objective：To explore the change of blood levels and clinical significance of the b-type brain natriuretic peptide （ BNP） and the amino terminal b-type brain natriuretic peptide （NT - proBNP） in patients with heart failure （hereinafter referred to as the heart failure）. Method： 82 cases of heart failure patients who were admitted in our hospital from July 2013 to June 2014 were retrospective analyzed （heart failure group）. New York heart association （NYHA） standard cardiac function was used in patients with cardiac function classification and echocardiography was used to evaluate patients’ cardiac function. in the same period in the hospital， 60 cases of patients with normal cardiac function were selected as control group. All patients was drawn fasting venous blood. Two indicators，left ventricular ejection fraction （LVEF） and level of difference in patients with different cardiac function NYHA class were analyzed. Result： The blood BNP， NT - proBNP of the heart failure group were significantly higher than that of the control group， the difference was statistically significant （P0.01）. In the heart failure group， heart failure increaseed with NYHA classification， BNP， NT - proBNP level increased， the two indexes difference in different levels of cardiac function had s