TNF―α和IL―1β对新生儿缺血缺氧性脑病临床诊断价值.docVIP

TNF―α和IL―1β对新生儿缺血缺氧性脑病临床诊断价值 　　[摘要] 目的 探讨TNF-α和IL-1β对新生儿缺血缺氧性脑病的临床诊断价值。 方法 2013年1月～2014年5月收集我院新生儿科的住院新生儿50例，作为缺血缺氧性脑病组。对照组为同期正常出生的足月新生儿50例。分别比较缺血缺氧性脑病组和对照组在出生1 d及出生后7 d血清中TNF-α和IL-1β。结果 ①缺血缺氧性脑病组与对照组出生1 d及出生后7 d血清中TNF-α及IL-1β明显高于对照组，差异有统计学意义（P0.05）；②缺血缺氧性脑病组中死亡的患儿 TNF-α和IL-1β水平明显高于存活者（P0.05）。结论 TNF-α和IL-1β能够较好地反映新生儿缺血缺氧性脑病的程度，发生缺血缺氧性脑病死亡的患儿，体内TNF-α和IL-1β明显高于未发生死亡的患儿，TNF-α和IL-1β对诊断缺血缺氧性脑病有较高的临床价值。 　　[关键词] TNF-α；IL-1β；缺血缺氧性脑病；新生儿 　　[中图分类号] R722.1 [文献标识码] B [文章编号] 1673-9701（2015）34-0058-03 　　The clinical diagnostic value of TNF-α and IL-1β in neonatal hypoxic ischemic encephalopathy 　　CHEN Beiyang 　　Department of Infectious Diseases，Ruijin Women and Childrens Hospital in Jiangxi Province， Ruijin 342500，China 　　[Abstract] Objective To investigate the clinical diagnostic value of TNF-and IL-1 in neonatal hypoxic ischemic encephalopathy. Methods A total of 50 patients with neonatal department of our hospital were collected from January 2013 to May 2014（HIE group）. The control group （50 cases） was term newborns with normal birth. IL-1β and TNF-α were compared between the control group and at 1 day and 7 days after birth. Results （1）The serum levels of IL-1β and TNF-α were significantly higher than those of the control group， and the difference was statistically significant（P0.05）. （2）The TNF-α and IL-1β levels in the death of the HIE group were significantly higher than those of the surviving children（P0.05）. Conclusion TNF-α and IL-1β can better respond to neonatal hypoxic ischemic encephalopathy， and TNF-α and IL-1β in the IL-1 and IL-1 are higher than those in the patients with hypoxic ischemic encephalopathy. 　　[Key words] TNF-α； IL-1β； Hypoxic ischemic encephalopathy； Newborn 　　新生儿缺氧缺血性脑病（hypoxic ischemic encephalopathy，HIE）临床表现有意识障碍、激惹、昏迷等表现，重症病例可表现为呼吸节律不齐、中枢性呼吸衰竭，是导致新生儿期死亡的重要疾病。因此正确评估及早期诊断新生儿脑细胞的损伤程度具有积极的临床意义。我们查阅近几年国内外文献，关于报道肿瘤坏死因子-α（TNF-α）和IL-1β（白细胞介素-1β）炎性因子在缺血缺氧性脑病中的发病地位较少报道。因此我们本次研究的目的为检测缺血缺氧性脑病新生儿TNF-α和IL-1β的动态水平，探讨其对诊断缺血缺氧性脑病的临床价值。 　　1 资料与方法 　　1.1