三联疗法治疗幽门螺杆菌相关性胃炎临床分析.docVIP

三联疗法治疗幽门螺杆菌相关性胃炎的临床分析 　　【摘要】 目的：观察奥美拉唑和埃索美拉唑三联疗法治疗幽门螺杆菌（Hp）相关性胃炎的疗效。方法：选取笔者所在医院2013年6月-2014年5月收治的280例Hp阳性的慢性胃炎患者，按照随机数字表法将其分为奥美拉唑组和埃索美拉唑组，各140例。奥美拉唑组采用奥美拉唑、左氧氟沙星和阿莫西林治疗，埃索美拉唑组则采用埃索美拉唑、左氧氟沙星和阿莫西林治疗。观察比较两组患者的Hp根治率、临床症状及组织学改善情况的差异。结果：埃索美拉唑组的Hp根除率81.43%（114/140）明显高于奥美拉唑组的69.29%（97/140），临床症状的临床控制率22.86%和总有效率92.14%均明显高于奥美拉唑组的14.29%和76.43%，组织学的临床控制率29.29%和总有效率65.00%均明显高于奥美拉唑组的17.86%和50.71%，差异均有统计学意义（P0.05）。结论：埃索美拉唑三联疗法治疗幽门螺杆菌相关性胃炎能有效提高Hp根除率，促进临床症状和病理组织学的改善，疗效优于奥美拉唑三联疗法，值得临床推广。 　　【关键词】 三联疗法； 幽门螺杆菌； 胃炎； 奥美拉唑； 埃索美拉唑 　　中图分类号 R573.3 文献标识码 A 文章编号 1674-6805（2015）1-0001-03 　　【Abstract】 Objective：To observe the curative effect of Omeprazole and Esomeprazole triple therapy for Helicobacter pylori（Hp） associated gastritis.Method：280 Hp positive patients with chronic gastritis in our hospital from June 2013 to May 2014 were selected，they were divided into the Omeprazole group and the Esomeprazole group according to the random number table method，140 cases in each group.The Omeprazole group was taken with Omeprazole，Amoxicillin and Levofloxacin for treatment.The Esomeprazole group was taken with Esomeprazole，Amoxicillin and Levofloxacin for treatment.The Hp cure rates and differences in clinical symptoms and histological improvement between the two groups were observed and compared.Result：Hp eradication rate of the Esomeprazole group was 81.43%（114/140），which was significantly higher than 69.29%（97/140） of the Omeprazole group，the clinical control rate and total effective rate of clinical symptoms improvement in the Esomeprazole group were 22.86% and 92.14%，which were significantly higher than 14.29% and 76.43% in the Omeprazole group，the clinical control rate and total effective rate of histological improvement in the Esomeprazole group were 29.29% and 65.00%，which were significantly higher than 17.86% and 50.71% in the Omeprazole group，the differences were statistically significant（P0.05）.Conclusion：The Esomeprazole triple therapy in the treatment of Helicobacter pylori-associat