两种不同剂量静脉滴注丙种球蛋白治疗川崎病临床疗效评价.docVIP

两种不同剂量静脉滴注丙种球蛋白治疗川崎病的临床疗效评价 　　[摘要] 目的 观察并对比两种大剂量静脉滴注丙种球蛋白方案治疗川崎病的效果。方法 回顾性分析总结该院2005年3月―2014年3月收治的84例患小儿川崎病儿童。分成单剂给药组和连续给药组，单剂给药组直接静脉滴注蓉生静丙2 g/d，同时连续给药组静脉滴注蓉生静丙1 g，连续给药2 d，观察两组患儿急性临床症状消退时间和各项实验室指标前后变化及冠状动脉内径恢复情况，对比二者疗效。结果 单剂给药组患儿发热消退时间较短于连续给药组，P0.05）。单剂给药组患儿治疗后冠状动脉扩张均有好转迹象，单剂给药组患儿恢复例数明显多于对照组，两组比较差异有统计学意义（χ2=4.3721，P=0.0365）。两组患儿治疗前C反应蛋白、红细胞沉降率、白细胞、血小板计数均差异无统计学意义，治疗后两组患儿之间C反应蛋白和红细胞沉降率差异有统计学意义（P0.05）。结论 对于治疗川崎病单次给药剂量2 g/d的效果要好于1 g连续给药2 d的给药方式。单次给药2 g/d治疗川崎病有较好的疗效，值得广泛使用于临床当中。 　　[关键词] 大剂量；丙种球蛋白；川崎病；疗效 　　[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-0742（2014）11（c）-0010-02 　　[Abstract] Objective To study and compare the effect of intravenous drip of two kinds of high-dose gamma globulin in the treatment of Kawasaki disease. Methods 84 cases of children suffering from Kawasaki disease admitted in our hospital from March 2005 to March 2014 were analyzed and summarized retrospectively. The patients were divided into the single-dose administration group and successive administration group. The single-dose administration group was treated by intravenous drip of Rongsheng IVIG 2g/d， the successive administration group was treated by intravenous drip of Rongsheng IVIG 1g/d for 2 days. The acute clinical symptoms subsiding time， the changes in various laboratory parameters and recovery of coronary artery internal diameter of the two groups were observed and the efficacy was compared between the two groups. Results The fever subsiding time of the single-dose administration group was shorter than that of the successive administration group with statistical significance， P0.05）. After treatment， the coronary artery dilatation of the children in the single-dose administration group improved， the proportion of the children with recovery in the single-dose administration group was much more than that in the successive administration group with statistical significance（χ2=4.3721，P=0.0365） . Before treatment， there were no statistically significant differences in C-reactive protein， erythr