不同剂量螺内酯对慢性充血性心力衰竭患者血浆B型脑钠肽的影响-心血管内科专业论文.docxVIP

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不同剂量螺内酯对慢性充血性心力衰竭患者血浆B型脑钠肽的影响-心血管内科专业论文.docx

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不同剂量螺内酯对慢性充血性心力衰竭患者血浆B型脑钠肽的影响-心血管内科专业论文

万方数据万方数据关键词：慢性充血性心力衰竭、B 型脑钠肽、螺内酯、肾素-血管紧张素-醛固酮系统。 III Different dose of spironolactone in patients with chronic congestive heart failure b-type brain natriuretic effects. [Abstract] : Objective: Based on the different dose of spironolactone in patients with chronic congestive heart failure (CHF) b-type brain natriuretic peptide (BNP), the influence of spironolactone in optimal dose in the treatment of heart failure patients. Methods: In 2013, 2014-2-3 primary hypertension and coronary atherosclerotic heart disease (ischemic cardiomyopathy) lead to level 3, 211 patients with chronic congestive heart failure, accept the CHF, on the basis of routine treatment, were randomly divided into 4 groups, respectively taking spironolactone 0 mg (group A) 20 mg (group B) 40 mg (group C) 60 mg (group D), treatment for 10 days monitoring patients BNP EF % value changes of 6 minutes walk test Exclusion criteria: potassium 4.5 mg/l, in patients with serum creatinine 222.5 umol/l, lung disease Liver and kidney function is not complete, thyroid diseases, connective tissue diseases, diseases of the blood system and so on. Results ：1 after treatment group A and group B, C, D group patients degree of plasma BNP concentration decreased respectively: 20.7%, 38.6%, 48.4%, 38.6%; Group A and group B, group C, group D compare BNP decreased degree difference was statistically significant (P 0.05); Among them, group C and D are statistically significant differences between group A (P 0.01). 2. After treatment group A and group B, group C, group D heart failure patients with higher EF % values differences between groups have no statistical significance (P 0.05). 3. After treatment in patients with heart failure monitoring before 6 minutes walking distance from treatment have been extended, is 364.6 meters in group A and group B respectively 385.5 meters and 413.5 meters in group C, group D is 448.5 meters. C, group D and group A compared with group B and D group were significant statistic