尼可地尔治疗舒张性心力衰竭临床疗效观察.docVIP

尼可地尔治疗舒张性心力衰竭临床疗效观察 　　【摘要】 目的：观察尼可地尔对舒张性心力衰竭患者的临床疗效。方法：选择2012年7月-2014年12月于本院心内科住院诊疗的DHF患者70例，按照随机数字表法将其分为对照组和治疗组，每组35例。对照组给予舒张性心力衰竭的常规治疗，治疗组在给予舒张性心力衰竭常规治疗的同时口服尼可地尔，5 mg/次，3次/d，疗程12周。观察两组患者的临床疗效、治疗前后二尖瓣舒张早期流速峰值（E）、二尖瓣舒张晚期流速峰值（A）、二尖瓣环舒张早期流速峰值（e?）、E/A、E/e?、N末端脑钠肽前体（NT-proBNP）及6 min步行试验距离（6MWT）。同时监测药物不良反应。结果：经12周治疗后，治疗组的显效率及总有效率均明显高于对照组，差异均有统计学意义（P0.05）。两组治疗后E、e?、E/A及6 min步行试验距离较治疗前均明显升高，A、E/e?及NT-proBNP水平较治疗前均明显降低，且治疗组的改善水平均明显优于对照组，差异均有统计学意义（P0.05或P0.01）。两组均无明显不良反应。结论：舒张性心力衰竭患者在常规治疗的同时口服尼可地尔能够有效改善临床症状及心功能。 　　【关键词】 尼可地尔； 舒张性心力衰竭； N末端脑钠肽前体 　　【Abstract】 Objective：To observe the therapeutic effect of Nicorandil for the treatmnet of diastolic heart failure.Method：Seventy patients with diastolic heart failure admitted to Department of cardiology in our hospital from July 2012 to December 2014 were selected and divided into the control group and the treatment group according to the random number table method，35 cases in each group.The control group received routine treatment for diastolic heart failure，while the treatment group was given Nicorandil（5 mg per time，3 times a day for 12 weeks） on the basis of routine treatment.The therapeutic effect，early diastolic velocity of mitral valve（E），peak diastolic velocity of mitral valve（A），early diastolic velocity of mitral annulus（e?），E/A，E/e?，NT-proBNP and 6MWT between the two groups were observed and compared before and after 12 weeks’treatment，and the adverse drug reactions were monitored at the same time.Result：After 12 weeks’treatment，the marked effective rate and total effective rate of the treatment group were significantly higher than those of the control group，the differences were statistically significant（P0.05）.The E，e?，E/A and 6MWT of the two groups after treatment were significantly higher than before treatment，the A，E/e? and NT-proBNP level of the two groups after treatment were significantly lower than before treatment，and the improvement levels of above indexes in the treatment group were significantly better than