巴曲酶治疗突发性耳聋临床疗效评价.docVIP

巴曲酶治疗突发性耳聋临床疗效评价 　　【摘要】 目的 探讨巴曲酶治疗突发性耳聋的临床疗效。方法 80例突发性耳聋患者， 随机分为对照组和观察组， 每组40例。对照组给予患者常规治疗， 观察组患者在常规治疗基础上给予巴曲酶治疗， 对两组患者的治疗效果、血流量变化情况进行对比分析。结果 观察组患者治疗总有效率为95.00%， 明显高于对照组的80.00%， 差异具有统计学意义（P0.05）。治疗后， 两组患者的全血粘度、血浆粘度、全血还原粘度及纤维蛋白原均较治疗前有所改善， 且观察组患者的全血粘度、血浆粘度、全血还原粘度及纤维蛋白原低于对照组， 差异具有统计学意义（P0.05）。结论 在常规治疗的基础上给予患者巴曲酶治疗效果突出， 值得临床应用。 　　【关键词】 巴曲酶；突发性耳聋；临床疗效 　　DOI：10.14163/j.cnki.11-5547/r.2017.15.045 　　Evaluation of clinical effect by batroxobin in the treatment of sudden hearing loss HUANG Yan-yun， LI Zhi-hui， WANG Ke-xiong， et al. Department of Otorhinolaryngology， Guangdong Foshan City Sanshui District People’s Hospital， Foshan 528100， China 　　【Abstract】 Objective To investigate clinical effect by batroxobin in the treatment of sudden hearing loss. Methods A total of 80 patients with sudden hearing loss were randomly divided into control group and observation group， with 40 cases in each group. The control group received conventional therapy， and the observation group received additional batroxobin to conventional therapy. Comparative analysis was made on curative effect and changes in blood flow volume between the two groups. Results The observation group had obviously higher total effective rate in treatment as 95.00% than 80.00% in the control group， and their difference had statistical significance （P0.05）. After treatment， both groups had better whole blood viscosity， plasma viscosity， whole blood reductive viscosity， and fibrinogen than those before treatment. The observation group had all lower whole blood viscosity， plasma viscosity， whole blood reductive viscosity， and fibrinogen than the control group， and their difference had statistical significance （P0.05）. Conclusion Implement of batroxobin in addition to conventional therapy shows excellent curative effect， and it is worth clinical application. 　　【Key words】 Batroxobin； Sudden hearing loss； Clinical effect 　　突?l性耳聋是一种耳鼻喉科较为常见临床急症， 指的是患者突然发生不明原因的感音神经性听力损失， 至少在相邻的两个频率听力下降≥20 dBHL， 并在72 h内达峰值。患者除有不同程度的听力