急性心肌梗死溶栓治疗前后YKL40变化及意义.docVIP

急性心肌梗死溶栓治疗前后YKL40变化及意义 　　[摘要] 目的：探讨血清甲壳质酶蛋白40（YKL-40）在非ST段抬高心肌梗死和ST段抬高心肌梗死溶栓再通前后的变化及意义。方法：测定17例ST段抬高心肌梗死患者溶栓前及再通后YKL-40的水平，18例非ST段抬高心肌梗死患者YKL-40水平及20例健康状况良好、未发现心脏相关疾病健康体检者血清中的YKL-40，分别比较ST段抬高心肌梗死溶栓前与非ST段抬高心肌梗死及健康体检者的差异以及ST段抬高心肌梗死溶栓再通前后的差异。结果：ST段抬高心肌梗死患者溶栓前血清YKL-40水平[（157.56±52.35）μg/L（75.02～558.04 μg/L）]，显著高于健康体检组[（97.3±36.04）μg/L（53.2～199.05 μg/L）]（P0.05）。结论：血清YKL-40水平检测在急性心肌梗死的早期诊断、治疗效果方面有较大的临床价值。 　　[关键词] 血清甲壳质酶蛋白40；急性心肌梗死；溶栓 　　[中图分类号] R542.2[文献标识码]Ａ [文章编号]1673-7210（2011）07（c）-060-03 　　 　　Changes and significance of YKL-40 after thrombolytic therapy for acute myocardial infarction 　　ZHOU Li, SUN Honglei, BI Meijuan 　　Cardiovascular Department, the Central Hospital of Jiaozuo Coal Group, He′nan Province, Jiaozuo 454100, China 　　[Abstract] Objective: To investigate the changes and its significance caused by serum enzyme chitin 40 (YKL-40) after thrombolytic therapy for non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction. Methods: The serum YKL-40 levels of 17 patients with ST-segment elevation myocardial infarction before and after thrombolytic treatment, 18 patients with non-ST-segment elevation myocardial infarction and 20 healthy people without any detected heart related diseases were detected. The patients with ST-segment elevation myocardial infarction before thrombolytic treatment was compared to patients with non-ST-segment elevation myocardial infarction, healthy people and patients with ST-segment elevation myocardial infarction after thrombolytic treatment. Results: The serum YKL-40 level of patients with ST-segment elevation myocardial infarction before thrombolytic treatment was [(157.56±52.35) μg/L(75.02-558.04 μg/L)], which was significantly higher than [(97.3±36.04) μg/L (53.2-199.05 μg/L)] of healthy people (P0.05). Conclusion: Early diagnosis of serum YKL-40 levels in the patients with acute myocardial infarction has important clinical value in therapeutic effects. 　　[Key words] Serum enzyme chitin